Evidence map›Paper›PMID 24199024›Full record

ReviewWorld journal of gastrointestinal pharmacology and therapeutics2013

Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia.

Craig A Friesen, Jennifer V Schurman, Jennifer M Colombo, Susan M Abdel-Rahman

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastrointestinal pharmacology and therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Observational
  11. Review
  12. Article
  13. Functional dyspepsia: new insights into pathogenesis and therapy.The Korean journal of internal medicine · 2016
    Review
  14. Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study.World journal of gastrointestinal pharmacology and therapeutics · 2016
    Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Craig A FriesenCraig A Friesen, Jennifer M Colombo, Division of Gastroenterology, Hepatology and Nutrition, the Children's Mercy Hospital and Clinics, Kansas City, Missouri, MO 64108, United States.
Jennifer V Schurman
Jennifer M Colombo
Susan M Abdel-Rahman
Children's Mercy Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia (FD). Importantly, inflammation may serve as a mediator between psychologic and physiologic functions. This manuscript reviews the literature implicating two inflammatory cell types, mast cells and eosinophils, in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD. There are a number of inciting events which may initiate an inflammatory response, and the subsequent recruitment and activation of mast cells and eosinophils. These include internal triggers such as stress and anxiety, as well as external triggers such as microbes and allergens. Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils. Evidence exists to suggest that combining "anti-inflammatory" medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD.

Indexed as

Abdominal painEosinophilsFunctional dyspepsiaMast cellsStress

Identifiers

PMID24199024
PMCPMC3817289
OpenAlexW2108935509

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.