SynthesisJournal of thrombosis and thrombolysis2014
Primary venous thromboembolism prophylaxis in patients with solid tumors: a meta-analysis.
Synthesis in Journal of thrombosis and thrombolysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer.Blood advances · 2021Guideline
- Driver Genes Associated With the Incidence of Venous Thromboembolism in Patients With Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Prevention of venous thromboembolism in patients with cancer with direct oral anticoagulants: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Parenteral anticoagulation in ambulatory patients with cancer.The Cochrane database of systematic reviews · 2017Pooled it
- High rates of venous thromboembolic events in patients undergoing systemic therapy for urothelial carcinoma: A systematic review and meta-analysis.Urologic oncology · 2016Pooled it
- New Oral Anticoagulants for Thromboprophylaxis in Patients with Cancer Receiving Chemotherapy: An Economic Evaluation in a Chinese Setting.Clinical drug investigation · 2020Article
- Prevention of Venous Thromboembolism in Pancreatic Cancer: Breaking Down a Complex Clinical Dilemma.The oncologist · 2020Review
- Cortical blindness due to cerebral infarct in advanced pancreatic cancer.BMJ case reports · 2019Article
- Performance of Current Thromboembolism Risk Assessment Tools in Patients With Gastric Cancer and Validity After First Treatment.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
- Thromboprophylaxis and the route of administration of chemotherapy in testicular cancer patients in German-speaking countries.World journal of urology · 2018Article
- Predictors of Early Mortality in Cancer-Associated Thrombosis: Analysis of the RIETE Database.TH open : companion journal to thrombosis and haemostasis · 2018Article
- Predictors of active cancer thromboembolic outcomes: role of body composition.International angiology : a journal of the International Union of Angiology · 2017Article
- Predictors of active cancer thromboembolic outcomes: validation of the Khorana score among patients with lung cancer.Journal of thrombosis and haemostasis : JTH · 2016Article
- Prospective evaluation of protein C and factor VIII in prediction of cancer-associated thrombosis.Thrombosis research · 2015Article
- Primary thromboprophylaxis in patients with solid cancers.Journal of thrombosis and thrombolysis · 2015Article
- Primary venous thromboembolism prophylaxis in patients with solid tumors.Journal of thrombosis and thrombolysis · 2015Article
- Early venous thromboembolic events are associated with worse prognosis in patients with lung cancer.Lung cancer (Amsterdam, Netherlands) · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Venous thromboembolism (VTE) is a leading cause of death among outpatient chemotherapy patients. However the VTE preventive measures for outpatients are not widely advocated. We did a meta-analysis to evaluate the outpatient VTE prevention's effectiveness and safety. We searched electronic databases until the end of December 2012 and reviewed the abstracts and manuscripts following the PRISMA guidelines. Occurrence of first VTE event was the efficacy outcome. The safety end point was major bleeding. We calculated Q statistic and a homogeneity formal test. The odds ratio (OR) estimates were pooled by using the Mantel-Haenszel fixed-effects method in the absence of heterogeneity. Data were analyzed using the R META package). We identified 1,485 articles and reviewed 37 articles based on initial screening. The number of patients included in 11 selected trials was 7,805. The odds of VTE was lower in the prophylaxis group (OR 0.56; 95% CI 0.45-0.71) and improved when heparin-based prevention was analyzed (OR 0.53; 95% CI 0.41-0.70). We found strong prevention among patients with lung cancer (OR 0.46; 95% CI 0.29-0.74) and pancreatic cancer (OR 0.33; 95% CI 0.16-0.67). Major bleeding events were frequent in the intervention group (OR 1.65; 95% CI 1.12-2.44). Thromboprophylaxis reduced VTE episodes. The VTE events were reduced by 47% in heparin-based prophylaxis trials compared to placebo. The patients receiving heparin-based prophylaxis had a 60% increase in bleeding events. Improving risk stratification tools to personalize prevention strategies may enhance the VTE prevention applicability in cancer patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.