ArticleThe Journal of physiology2014
Positron emission tomography detects greater blood flow and less blood flow heterogeneity in the exercising skeletal muscles of old compared with young men during fatiguing contractions.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Changes in intramuscular blood flow and muscle deoxygenation at different parts of the vastus lateralis during intermittent isometric knee extension in young adult males.Physiological reports · 2026Article
- Quantification of Skeletal Muscle Perfusion in Feet and Lower Legs of Patients with T2DM and Diabetic Foot Ulcers Using [Journal of clinical medicine · 2025Article
- Simultaneous assessment of blood flow changes in femoral artery and skeletal muscle microvasculature using pulsed-wave and power Doppler ultrasonography.European journal of applied physiology · 2025Article
- Total-Body PET Imaging of Musculoskeletal Disorders.PET clinics · 2021Review
- Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds: A Preliminary Study.Military medicine · 2020Article
- Methods for the determination of skeletal muscle blood flow: development, strengths and limitations.European journal of applied physiology · 2018Review
- Reliability of muscle blood flow and oxygen consumption response from exercise using near-infrared spectroscopy.Experimental physiology · 2018Article
- Reduced blood flow to contracting skeletal muscle in ageing humans: is it all an effect of sand through the hourglass?The Journal of physiology · 2016Review
- Regulation of skeletal muscle blood flow during exercise in ageing humans.The Journal of physiology · 2016Review
- Muscle microvasculature's structural and functional specializations facilitate muscle metabolism.American journal of physiology. Endocrinology and metabolism · 2016Review
- Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Evidence of Preserved Oxidative Capacity and Oxygen Delivery in the Plantar Flexor Muscles With Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States.Exercise and sport sciences reviews · 2015Review
- Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms.American journal of physiology. Heart and circulatory physiology · 2014Article
- Heterogeneity of blood flow: impact of age on muscle specific tissue perfusion during exercise.The Journal of physiology · 2014Article
- Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [(18)F]-FDG PET/CT.Frontiers in physiology · 2014Article
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7 authors at 4 institutions in 3 countries.
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Abstract
The purpose of this study was to investigate blood flow and its heterogeneity within and among the knee muscles in five young (26 ± 6 years) and five old (77 ± 6 years) healthy men with similar levels of physical activity while they performed two types of submaximal fatiguing isometric contraction that required either force or position control. Positron emission tomography (PET) and [(15)O]-H2O were used to determine blood flow at 2 min (beginning) and 12 min (end) after the start of the tasks. Young and old men had similar maximal forces and endurance times for the fatiguing tasks. Although muscle volumes were lower in the older subjects, total muscle blood flow was similar in both groups (young men: 25.8 ± 12.6 ml min(-1); old men: 25.1 ± 15.4 ml min(-1); age main effect, P = 0.77) as blood flow per unit mass of muscle in the exercising knee extensors was greater in the older (12.5 ± 6.2 ml min(-1) (100 g)(-1)) than the younger (8.6 ± 3.6 ml min(-1) (100 g)(-1)) men (age main effect, P = 0.001). Further, blood flow heterogeneity in the exercising knee extensors was significantly lower in the older (56 ± 27%) than the younger (67 ± 34%) men. Together, these data show that although skeletal muscles are smaller in older subjects, based on the intact neural drive to the muscle and the greater, less heterogeneous blood flow per gram of muscle, old fit muscle achieves adequate exercise hyperaemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.