ArticleJournal of women's health (2002)2014
Predictors of improvement in endothelial function after exercise training in a diverse sample of postmenopausal women.
Article in Journal of women's health (2002), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03355469 (Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis.Frontiers in physiology · 2021Pooled it
- Acute impact of inorganic nitrate supplementation after ischemia and during small muscle mass exercise in postmenopausal females: A pilot study.Physiological reports · 2024Trial
- The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Protein-Added Healthy Lunch-Boxes Combined with Exercise for Improving Physical Fitness and Vascular Function in Pre-Frail Older Women: A Community-Based Randomized Controlled Trial.Clinical interventions in aging · 2023Trial
- Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.Journal of diabetes research · 2019Trial
- Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause.Experimental physiology · 2026Review
- Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Effects of regular exercise on vascular function with aging: Does sex matter?American journal of physiology. Heart and circulatory physiology · 2024Review
- Detrimental Changes in Health during Menopause: The Role of Physical Activity.International journal of sports medicine · 2023Review
- Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females.Physiological reports · 2022Article
- Promoting healthy cardiovascular aging: emerging topics.The journal of cardiovascular aging · 2022Article
- Aerobic exercise training and vascular function with ageing in healthy men and women.The Journal of physiology · 2019Review
- The Protective Role of Regular Aerobic Exercise on Vascular Function with Aging.Current opinion in physiology · 2019Article
- Follicle-stimulating hormone, but not cardiorespiratory fitness, is associated with flow-mediated dilation with advancing menopausal stage.Menopause (New York, N.Y.) · 2019Article
- Exercise Improves Vascular Function, but does this Translate to the Brain?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Extracellular Vesicles: A Novel Target for Exercise-Mediated Reductions in Type 2 Diabetes and Cardiovascular Disease Risk.Journal of diabetes research · 2018Review
- Vascular Adaptations to Habitual Exercise in Older Adults: Time for the Sex Talk.Exercise and sport sciences reviews · 2017Review
- Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity.Obesity (Silver Spring, Md.) · 2016Article
- Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism.Reviews in endocrine & metabolic disorders · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEndothelial dysfunction measured via flow-mediated dilation (FMD) is associated with greater risk of future hypertension and cardiovascular events in postmenopausal women. Aerobic exercise training has been shown to improve endothelial function in Caucasian populations, but has not been evaluated specifically in African Americans. This has clinical importance due to the increased prevalence of cardiovascular disease in African Americans.
methodsIn the present pilot study, 8 African American (age: 55.8±1.7 years, peak oxygen uptake [VO2 peak]: 21.0±3.9 mL/kg/minute, body mass index [BMI]: 30.1± 6.3 kg/m(2)) and 16 Caucasian (age: 57.2±5.9 years, VO2 peak: 21.8±3.7 mL/kg/minute, BMI: 29.3±5.2 kg/m(2)) sedentary postmenopausal women underwent brachial artery FMD measurements before and after 12 weeks of aerobic exercise training. FMD was quantified by comparing B-mode ultrasound images of the brachial artery at rest and following reactive hyperemia after 5 minutes of forearm occlusion. Participants performed aerobic exercise training 4 days per week for 12 weeks.
resultsDespite improvements in fitness in both groups, aerobic exercise training did not significantly improve FMD in African American (5.8% to 5.7%, p=0.950) or Caucasian postmenopausal women (5.7% to 6.6%, p=0.267). In women with the greatest impairment in endothelial function at baseline (FMD<4.5%), a significant improvement in FMD was observed, independent of race, following exercise training (2.2% to 6.2%, p=0.007).
conclusionThe benefits of aerobic exercise training on endothelial function in postmenopausal women are most pronounced in women with endothelial dysfunction prior to training and do not appear to be affected by race.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.