ArticleThe Journal of clinical investigation1986
Epitopes of apolipoprotein B-100 and B-48 in both liver and intestine. Expression and evidence for local synthesis in recessive abetalipoproteinemia.
Article in The Journal of clinical investigation, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 64 citations in OpenAlex.
- Development and partial characterisation of an antiserum against apolipoprotein B of the short-finned eel, Anguilla australis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Elevated triglyceride-rich lipoproteins in diabetes. A study of apolipoprotein B-48.Acta diabetologica · 1996Article
- Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia.American journal of human genetics · 1995Article
- Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.The Journal of clinical investigation · 1991Article
- Exclusion of linkage between the human apolipoprotein B gene and abetalipoproteinemia.American journal of human genetics · 1990Article
- Apolipoproteins in lipid transport, an impressionist view.Postgraduate medical journal · 1989Review
- Genetic evidence from two families that the apolipoprotein B gene is not involved in abetalipoproteinemia.The Journal of clinical investigation · 1988Article
- Truncated variants of apolipoprotein B cause hypobetalipoproteinaemia.Nucleic acids research · 1988Article
- Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of apolipoprotein (apo) B in liver and intestine from a patient with abetalipoproteinemia was evaluated by immunohistochemistry with a polyclonal and six monoclonal antibodies to different apo B-48 and B-100 epitopes. In normal liver, apo B was present inside and outside hepatocytes. The patients liver exhibited staining in the cytoplasm with the polyclonal and three monoclonal antibodies. By immunoelectron-microscopy, apo B was found to be present in the smooth endoplasmatic reticulum and the Golgi complex. Normal intestinal epithelium was labeled with polyclonal and all monoclonal antibodies, including those specific for apo B-100. The patients epithelium stained with polyclonal and six monoclonals, and apo B was present in the Golgi complex. Thus, normal intestinal mucosa expressed apo B-48 and B-100 epitopes, which indicates apo B-100 synthesis in the gut. The synthesis of the apo B molecule in the patient seems to be retained in both liver and gut, which suggests a posttranslational defect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.