SynthesisBMC genomics2013
Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach.
Synthesis in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 5 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Effects of folic acid with vitamin B12/vitamin B6 intervention on serum homocysteine metabolism and complications in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Serum homocysteine level and gestational diabetes mellitus: A meta-analysis.Journal of diabetes investigation · 2016Pooled it
- Evaluation of an Association of Blood Homocysteine Levels With Gastric Cancer Risk From 27 Case-Control Studies.Medicine · 2016Pooled it
- Pooled it
- MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.PloS one · 2015Pooled it
- Values of H-Type Hypertension in Patients with Large Vessel Occlusion.Clinical interventions in aging · 2024Trial
- Prevalence of Hyperhomocysteinaemia and Associated Factors among Ethiopian Adult Population in a 2015 National Survey.BioMed research international · 2020Trial
- Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects.BioMed research international · 2015Trial
- Impacts of maternal lipid and homocysteine levels on the risks of pregnancy complications and adverse outcomes in both singleton and twin pregnancies: a population-based observational cohort study.BMC pregnancy and childbirth · 2026Observational
- Transsulfuration Pathway Products and HInternational journal of molecular sciences · 2025Review
- An indicator of antioxidant stress ability to evaluate neurofunctional changes in patients with acute ischemic stroke: preliminary findings.BMC neurology · 2025Article
- Association of folate levels with all-cause and cause-specific mortality in patients with arthritis.Clinical rheumatology · 2025Article
- Article
- Association of homocysteine and uric acid with type 2 diabetes mellitus: a case-control study.Scientific reports · 2025Article
- Immunometabolic profiling related with gestational diabetes mellitus: a nested case-control study of CD4Acta diabetologica · 2025Article
- Association between homocysteine and severe cerebral small vessel disease burden in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Article
- Elevated homocysteine levels predict impaired liver and renal function in women of reproductive age with polycystic ovary syndrome: aFrontiers in nutrition · 2025Article
- The interplay between diabetes and atherosclerosis: A review of pathophysiological mechanisms.ARYA atherosclerosis · 2025Review
- Association between homocysteine levels and mortality in CVD: a cohort study based on NHANES database.BMC cardiovascular disorders · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe tested the hypothesis that elevated homocysteine (Hcy) level is causally associated with increased risk of type 2 diabetes mellitus (T2DM).
resultsThe meta-analysis and Mendelian randomization analysis were performed among 4011 cases and 4303 controls. The absolute pooled mean Hcy concentration in subjects with MTHFR 677TT was 5.55 μmol/L (95% CI, 1.33 to 9.77) greater than that in subjects with MTHFR 677CC in T2DM. Overall, the T allele of the MTHFR 677 C > T conferred a greater risk for T2DM [Random effect (RE) OR = 1.31(1.17-1.64), I² = 41.0%, p = 0.055]. The random effect (RE) pooled OR associated with T2DM for MTHFR 677TT relative to the 677CC was [RE OR = 1.38(1.18-1.62)]. The fixed-effect pooled OR of the association for the MTHFR 677 TT vs CT was 1.29 (95% CI, 1.09-1.51). MTHFR 677 TT showed a significantly higher risk for T2DM compared with MTHFR 677 CC + CT [Fixed effect (FE) OR = 1.32(1.14-1.54), I² = 0.0%, p = 0.686]. The absolute pooled mean Hcy concentration in individuals with T2DM was 0.94 μmol/L (95% CI, 0.40-1.48) greater than that in control subjects. The estimated causal OR associated with T2DM was 1.29 for 5 μmol/L increment in Hcy.
conclusionsOur findings provided strong evidence on the causal association of Hcy level with the development of T2DM.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.