Evidence map›Paper›PMID 24326981›Full record

Trial reportEuropean journal of nutrition2014

The effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial.

A M Alavi Naeini, I Elmadfa, A Djazayery, M Barekatain, M R Aghaye Ghazvini, M Djalali, A Feizi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017
    Pooled it
  9. Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017
    Pooled it
  10. Recommendations on screening for cognitive impairment in older adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016
    Guideline
  11. Trial
  12. Trial
  13. Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.Journal of alternative and complementary medicine (New York, N.Y.) · 2018
    Trial
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A M Alavi NaeiniSchool of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
I Elmadfa
A Djazayery
M Barekatain
M R Aghaye Ghazvini
M Djalali
A Feizi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran.

methodsAbout 256 elderly with mild cognitive impairment, aged 60-75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year.

backgroundDemographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined.

resultsAntioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively).

conclusionDespite significant improvement in most of the oxidative stress biomarkers, antioxidants' supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected.

Indexed as

Dietary Supplements8-Hydroxy-2'-DeoxyguanosineAgedAntioxidantsAscorbic AcidCognitionCognitive DysfunctionDeoxyguanosineDouble-Blind MethodFemaleGlutathioneHumansIranMaleMalondialdehydeMiddle Aged8-Hydroxy-2'-DeoxyguanosineAntioxidantsAscorbic AcidDeoxyguanosineGlutathioneMalondialdehydeVitamin E

Identifiers

PMID24326981

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.