ReviewBMC medicine2013
Potential involvement of the extracranial venous system in central nervous system disorders and aging.
Review in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall.PloS one · 2018Trial
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Anatomical Reasons for an Impaired Internal Jugular Flow.Medicina (Kaunas, Lithuania) · 2025Review
- Blood Flow in the Internal Jugular Veins in the Lateral Decubitus Body Position in the Healthy People.Journal of clinical medicine · 2025Article
- Case Report: Isolated surgical decompression for compressive internal jugular vein stenosis: case series and literature review.Frontiers in surgery · 2025Article
- Revisiting Virchow's triad: exploring the cellular and molecular alterations in cerebral venous congestion.Cell & bioscience · 2024Article
- Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior.Cell & bioscience · 2024Article
- Extreme lateral infracondylar approach for internal jugular vein compression syndrome: A case series with preliminary clinical outcomes.Acta neurochirurgica · 2023Article
- Cerebral venous congestion alters brain metabolite profiles, impairing cognitive function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Long-term safety and efficacy of stenting on correcting internal jugular vein and cerebral venous sinus stenosis.Annals of clinical and translational neurology · 2023Article
- Results of Numerical Modeling of Blood Flow in the Internal Jugular Vein Exhibiting Different Types of Strictures.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis.International journal of molecular sciences · 2021Article
- Review
- Pathogenesis and Management in Cerebrovenous Outflow Disorders.Aging and disease · 2021Review
- Eye-Neck Integrated Ultrasound in Idiopathic Intracranial Hypertension and Cerebral Venous Sinus Thrombosis.Frontiers in neurology · 2021Article
- Use of patient-reported data in determining factors contributing to internal jugular vein stenosis outcomes.Annals of translational medicine · 2020Article
- Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms.Frontiers in neurology · 2020Article
- Cervical spondylotic internal jugular venous compression syndrome.CNS neuroscience & therapeutics · 2020Article
- Venous and Arterial Responses to Partial Gravity.Frontiers in physiology · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the extracranial venous system in the pathology of central nervous system (CNS) disorders and aging is largely unknown. It is acknowledged that the development of the venous system is subject to many variations and that these variations do not necessarily represent pathological findings. The idea has been changing with regards to the extracranial venous system. DISCUSSION: A range of extracranial venous abnormalities have recently been reported, which could be classified as structural/morphological, hemodynamic/functional and those determined only by the composite criteria and use of multimodal imaging. The presence of these abnormalities usually disrupts normal blood flow and is associated with the development of prominent collateral circulation. The etiology of these abnormalities may be related to embryologic developmental arrest, aging or other comorbidities. Several CNS disorders have been linked to the presence and severity of jugular venous reflux. Another composite criteria-based vascular condition named chronic cerebrospinal venous insufficiency (CCSVI) was recently introduced. CCSVI is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes that may interfere with normal venous outflow. SUMMARY: Additional research is needed to better define the role of the extracranial venous system in relation to CNS disorders and aging. The use of endovascular treatment for the correction of these extracranial venous abnormalities should be discouraged, until potential benefit is demonstrated in properly-designed, blinded, randomized and controlled clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.