Evidence map›Paper›PMID 24345592›Full record

ArticleJournal of the American College of Cardiology2014

Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trøndelag Health Study), Norway.

Bjørn Mørkedal, Lars J Vatten, Pål R Romundstad, Lars E Laugsand, Imre Janszky

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 103 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 6 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03038620 phase4completedstarted 2017, after this paper: background citation

Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease

Ran2017Enrolled235Registered outcomes37Posted comparisons0ConditionsCardiovascular Diseases, Fat Disorder, Obesity, VisceralArmsliraglutide, Placebo
PMID 19853906PMID 21844879PMID 23812094PMID 25538311PMID 26768490PMID 25808071PMID 15810802PMID 16182882PMID 17549449PMID 17707180PMID 18340209PMID 18356555other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 6 syntheses or guidelines pooled it, 232 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Bjørn MørkedalDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway; Vestfold Hospital Trust, Tønsberg, Norway. Electronic address: bjorn@morkedal.com.
Lars J VattenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Pål R RomundstadDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Lars E LaugsandDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Imre JanszkyDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Norwegian University of Science and Technology · NONorwegian Institute of Public Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study sought to investigate whether obesity in the absence of metabolic abnormalities might be a relatively benign condition in relation to acute myocardial infarction (AMI) and heart failure (HF).

backgroundThe results of previous studies are conflicting for AMI and largely unknown for HF, and the role of the duration of obesity has not been investigated.

methodsIn a population-based prospective cohort study, a total of 61,299 men and women free of cardiovascular disease were classified according to body mass index (BMI) and metabolic status at baseline. BMI also was measured 10 and 30 years before baseline for 27,196 participants.

resultsDuring 12 years of follow-up, 2,547 participants had a first AMI, and 1,201 participants had a first HF. Compared with being normal weight (BMI <25 kg/m(2)) and metabolically healthy, the multivariable-adjusted hazard ratio (HR) for AMI was 1.1 (95% confidence interval [CI]: 0.9 to 1.4) among obese (BMI ≥30 kg/m(2)) and metabolically healthy participants and 2.0 (95% CI: 1.7 to 2.3) among obese and metabolically unhealthy participants. We found similar results for severe (BMI ≥35 kg/m(2)), long-lasting (>30 years), and abdominal obesity stratified for metabolic status. For HF, the HRs associated with obesity were 1.7 (95% CI: 1.3 to 2.3) and 1.7 (95% CI: 1.4 to 2.2) for metabolically healthy and unhealthy participants, respectively. Severe and long-lasting obesity were particularly harmful in relation to HF, regardless of metabolic status.

conclusionsIn relation to AMI, obesity without metabolic abnormalities did not confer substantial excess risk, not even for severe or long-lasting obesity. For HF, even metabolically healthy obesity was associated with increased risk, particularly for long-lasting or severe obesity.

Indexed as

Body Mass IndexCause of DeathAdultAgedAge FactorsCase-Control StudiesFemaleHeart FailureHumansMaleMetabolic SyndromeMiddle AgedMyocardial InfarctionObesityObesity, MorbidPrognosisepidemiologyheart failuremyocardial infarctionobesity

Identifiers

PMID24345592
OpenAlexW181700238

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.