SynthesisJournal of diabetes science and technology2013
Algorithms for a closed-loop artificial pancreas: the case for proportional-integral-derivative control.
Synthesis in Journal of diabetes science and technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02299479 (Adjusting Insulin Delivery to Activity), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adjusting Insulin Delivery to Activity (AIDA)
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Optimizing Hybrid Closed-Loop Therapy in Adolescents and Emerging Adults Using the MiniMed 670G System.Diabetes care · 2018Trial
- Closed-Loop Control Without Meal Announcement in Type 1 Diabetes.Diabetes technology & therapeutics · 2017Trial
- Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial.Diabetes care · 2017Trial
- Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas.Diabetes care · 2016Trial
- Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial.The Journal of clinical endocrinology and metabolism · 2015Trial
- Preliminary evaluation of a new semi-closed-loop insulin therapy system over the prandial period in adult patients with type 1 diabetes: the WP6.0 Diabeloop study.Journal of diabetes science and technology · 2014Trial
- Artificial Pancreas and Closed-Loop Insulin Delivery: From Early Concepts to AI-Driven Diabetes Automation.Biosensors · 2026Review
- A Hybrid Closed-Loop Blood Glucose Control Algorithm with a Safety Limiter Based on Deep Reinforcement Learning and Model Predictive Control.Biosensors · 2026Article
- Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025Review
- Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025Review
- Diabetes Technology Meeting 2021.Journal of diabetes science and technology · 2022Article
- Interval Safety Layer Coupled With an Impulsive MPC for Artificial Pancreas to Handle Intrapatient Variability.Frontiers in endocrinology · 2022Article
- Closed-loop control of continuous piperacillin delivery: AnFrontiers in bioengineering and biotechnology · 2022Article
- An In Silico Head-to-Head Comparison of the Do-It-Yourself Artificial Pancreas Loop and Bio-Inspired Artificial Pancreas Control Algorithms.Journal of diabetes science and technology · 2022Article
- Glucagon as a Therapeutic Approach to Severe Hypoglycemia: After 100 Years, Is It Still the Antidote of Insulin?Biomolecules · 2021Review
- The Closed-Loop System Improved the Control of a Pregnant Patient with Type 1 Diabetes Mellitus.Case reports in endocrinology · 2021Article
- Performance Analysis of Different Embedded Systems and Open-Source Optimization Packages Towards an Impulsive MPC Artificial Pancreas.Frontiers in endocrinology · 2021Article
- Embedded Model Predictive Control for a Wearable Artificial Pancreas.IEEE transactions on control systems technology : a publication of the IEEE Control Systems Society · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Closed-loop insulin delivery continues to be one of most promising strategies for achieving near-normal control of blood glucose levels in individuals with diabetes. Of the many components that need to work well for the artificial pancreas to be advanced into routine use, the algorithm used to calculate insulin delivery has received a substantial amount of attention. Most of that attention has focused on the relative merits of proportional-integral-derivative versus model-predictive control. A meta-analysis of the clinical data obtained in studies performed to date with these approaches is conducted here, with the objective of determining if there is a trend for one approach to be performing better than the other approach. Challenges associated with implementing each approach are reviewed with the objective of determining how these approaches might be improved. Results of the meta-analysis, which focused predominantly on the breakfast meal response, suggest that to date, the two approaches have performed similarly. However, uncontrolled variables among the various studies, and the possibility that future improvements could still be effected in either approach, limit the validity of this conclusion. It is suggested that a more detailed examination of the challenges associated with implementing each approach be conducted.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.