ReviewJournal of cardiology2014
Adipokines: a link between obesity and cardiovascular disease.
Review in Journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 273 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR Study
Role of Pre-operative Exercise and Nutrition Therapy on Insulin Resistance and Vascular Health in Patients Undergoing Bariatric Surgery
Who cites it
273 citing papers in PubMed, 8 syntheses or guidelines pooled it, 565 citations in OpenAlex.
- Social and Religious Networks with Respect to the Health Behaviors of African American Women: A Systematic Review.Journal of religion and health · 2025Pooled it
- Pooled it
- The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- The Benefits of Resistance Training in Obese Adolescents: A Systematic Review and Meta-analysis.Sports medicine - open · 2022Pooled it
- The Effect of Nutrition on Aging-A Systematic Review Focusing on Aging-Related Biomarkers.Nutrients · 2022Pooled it
- Risk Factors for Anthracycline-Induced Cardiotoxicity.Frontiers in cardiovascular medicine · 2021Pooled it
- Executive Functions in Predicting Weight Loss and Obesity Indicators: A Meta-Analysis.Frontiers in psychology · 2020Pooled it
- The effect of commitment-making on weight loss and behaviour change in adults with obesity/overweight; a systematic review.BMC public health · 2019Pooled it
- Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6-7 Years: A Follow-Up of a Randomized Controlled Trial.The Journal of nutrition · 2023Trial
- Resistance training decreases plasma levels of adipokines in postmenopausal women.Scientific reports · 2020Trial
- Vitamin D supplementation increases adipokine concentrations in overweight or obese adults.European journal of nutrition · 2020Trial
- Trial
- Article
- Inflammatory Adipokines and Potential Oxidative Stress-Related Mechanisms Linking MASLD with Subclinical Atherosclerosis Within CKM Syndrome: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2026Review
- Association of the ITLN1 gene polymorphism with dietary patterns, glycemic factors, and anthropometric indices in women with prediabetes.Genes & nutrition · 2026Article
- Beyond local injury: pathogenic roles of metabolic, endocrine, and aging-associated systemic factors in tendinopathy and novel therapeutic strategies.Journal of orthopaedic surgery and research · 2026Review
- Longitudinal Adipokine and Lipid Profiles in Fabry Disease.Journal of clinical medicine · 2026Article
- Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026Review
- Emerging quantitative CCTA imaging biomarkers for cardiovascular risk stratification: a narrative review.Frontiers in cardiovascular medicine · 2026Review
- The associations of the triglyceride-glucose index and estimated glucose disposal rate with incident cardiometabolic multimorbidity vary across obesity phenotypes: a longitudinal cohort study.Frontiers in nutrition · 2026Article
213 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is a risk factor for various cardiovascular diseases including hypertension, atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the microenvironment of adipose tissue and its impact on systemic metabolism have shed light on the pathogenesis of obesity-linked cardiovascular diseases. Adipose tissue functions as an endocrine organ by secreting multiple immune-modulatory proteins known as adipokines. Obesity leads to increased expression of pro-inflammatory adipokines and diminished expression of anti-inflammatory adipokines, resulting in the development of a chronic, low-grade inflammatory state. This adipokine imbalance is thought to be a key event in promoting both systemic metabolic dysfunction and cardiovascular disease. This review will focus on the adipose tissue microenvironment and the role of adipokines in modulating systemic inflammatory responses that contribute to cardiovascular disease.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.