ArticleGenes & nutrition2014
Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.
Article in Genes & nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Effect of Small-Quantity Lipid-Based Nutrient Supplementation on Children's Cortisol Concentration.Maternal & child nutrition · 2026Trial
- Human Nutrition Research in the Data Era: Results of 11 Reports on the Effects of a Multiple-Micronutrient-Intervention Study.Nutrients · 2024Review
- Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers.Diagnostics (Basel, Switzerland) · 2022Review
- Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents.Scientific reports · 2021Article
- An Integrated Multi-Disciplinary Perspectivefor Addressing Challenges of the Human Gut Microbiome.Metabolites · 2020Review
- Metabo groups in response to micronutrient intervention: Pilot study.Food science & nutrition · 2020Article
- Why Are Suicide Rates Increasing in the United States? Towards a Multilevel Reimagination of Suicide Prevention.Current topics in behavioral neurosciences · 2020Review
- Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications.European journal of nutrition · 2019Review
- Clinical and Vitamin Response to a Short-Term Multi-Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses.Molecular nutrition & food research · 2018Article
- Challenges in Personalized Nutrition and Health.Frontiers in nutrition · 2018Article
- Prenatal Nutritional Deficiency and Psychosis: Where Do We Go From Here?JAMA psychiatry · 2017Article
- The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility.Genes & nutrition · 2017Article
- Propelling the paradigm shift from reductionism to systems nutrition.Genes & nutrition · 2017Article
- A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases.Scientific reports · 2016Article
- Human nutrition, environment, and health.Genes & nutrition · 2015Article
- The genomics of micronutrient requirements.Genes & nutrition · 2015Article
- Enabling nutrient security and sustainability through systems research.Genes & nutrition · 2015Article
- Translational genomics.Applied & translational genomics · 2014Review
- Micronutrient research, programs, and policy: From meta-analyses to metabolomics.Advances in nutrition (Bethesda, Md.) · 2014Review
- Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop.Microbiome · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum's one gene-one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems' responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.