Evidence map›Paper›PMID 24366463›Full record

SynthesisPediatric research2013

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990.

Anne C C Lee, Naoko Kozuki, Hannah Blencowe, Theo Vos, Adil Bahalim, Gary L Darmstadt, Susan Niermeyer, Matthew Ellis, Nicola J Robertson, Simon Cousens and 1 more

Registry-linked trialOpen access · hybridAbstract readHistorical ArticleMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07743099 (Renal Oxygen Saturation Measured by Near-Infrared Spectroscopy for the Early Recognition of Acute Kidney Injury in Asphyxiated Neonates Undergoing Therapeutic Hypothermia), which is not on this map. Cited by 345 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
345citing papers in PubMed, 11 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07743099 completednot on this mapstarted 2021, after this paper: background citation

Renal Oxygen Saturation Measured by Near-Infrared Spectroscopy for the Early Recognition of Acute Kidney Injury in Asphyxiated Neonates Undergoing Therapeutic Hypothermia: A Prospective Observational Cohort Study

TypeobservationalSponsorAgah Bahadır Öztürk,MDRan2021 to 2021Enrolled46ConditionsHypoxic-Ischemic Encephalopathy, Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Neonatal, Asphyxia NeonatorumArms1- Continuous Cerebral Near-Infrared Spectroscopy, 2- Continuous Bilateral Renal Near-Infrared Spectroscopy
3 · Its place in the literature

Who cites it

345 citing papers in PubMed, 11 syntheses or guidelines pooled it, 645 citations in OpenAlex.

  1. Melatonin treatment for neonatal encephalopathy.The Cochrane database of systematic reviews · 2026
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  10. Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia.Annals of clinical and translational neurology · 2022
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285 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Anne C C LeeDepartment of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Naoko KozukiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Hannah BlencoweFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Theo VosInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington.
Adil BahalimThe Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.
Gary L DarmstadtFamily Health Division, Bill and Melinda Gates Foundation, Seattle, Washington.
Susan NiermeyerDepartment of Pediatrics, University of Colorado School of Medicine and Center for Global Health, Colorado School of Public Health, Aurora, Colorado.
Matthew EllisCentre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Nicola J RobertsonInstitute for Women's Health, University College London, London, UK.
Simon CousensFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Joy E Lawn1] MARCH (Maternal Reproductive & Child Health) Centre, London School of Hygiene and Tropical Medicine, London, UK [2] Saving Newborn Lives/Save the Children, Washington, DC.
London School of Hygiene & Tropical Medicine · GBBill & Melinda Gates Foundation · USBrigham and Women's Hospital · USCenter for Global Health · USGlobal Fund to Fight AIDS, Tuberculosis and Malaria · CHJohns Hopkins University · USLondon Women's Clinic · GBUniversity of Bristol · GBUniversity of Washington · US

Funding

Medical Research Council MR/K012126/1
6 · The paper itself

Abstract

backgroundIntrapartum hypoxic events ("birth asphyxia") may result in stillbirth, neonatal or postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of impairment outcomes are currently limited. Neonatal encephalopathy (NE) following an intrapartum hypoxic event is a strong predictor of long-term impairment.

methodsLinear regression modeling was conducted on data identified through systematic reviews to estimate NE incidence and time trends for 184 countries. Meta-analyses were undertaken to estimate the risk of NE by sex of the newborn, neonatal case fatality rate, and impairment risk. A compartmental model estimated postneonatal survivors of NE, depending on access to care, and then the proportion of survivors with impairment. Separate modeling for the Global Burden of Disease 2010 (GBD2010) study estimated disability adjusted life years (DALYs), years of life with disability (YLDs), and years of life lost (YLLs) attributed to intrapartum-related events.

resultsIn 2010, 1.15 million babies (uncertainty range: 0.89-1.60 million; 8.5 cases per 1,000 live births) were estimated to have developed NE associated with intrapartum events, with 96% born in low- and middle-income countries, as compared with 1.60 million in 1990 (11.7 cases per 1,000 live births). An estimated 287,000 (181,000-440,000) neonates with NE died in 2010; 233,000 (163,000-342,000) survived with moderate or severe neurodevelopmental impairment; and 181,000 (82,000-319,000) had mild impairment. In GBD2010, intrapartum-related conditions comprised 50.2 million DALYs (2.4% of total) and 6.1 million YLDs.

conclusionIntrapartum-related conditions are a large global burden, mostly due to high mortality in low-income countries. Universal coverage of obstetric care and neonatal resuscitation would prevent most of these deaths and disabilities. Rates of impairment are highest in middle-income countries where neonatal intensive care was more recently introduced, but quality may be poor. In settings without neonatal intensive care, the impairment rate is low due to high mortality, which is relevant for the scale-up of basic neonatal resuscitation.

Indexed as

Asphyxia NeonatorumCentral Nervous System DiseasesFemaleGlobal HealthHistory, 20th CenturyHistory, 21st CenturyHumansIncidenceLinear ModelsMaleMorbidityRisk AssessmentSex FactorsSocioeconomic FactorsSurvival Rate

Identifiers

PMID24366463
PMCPMC3873711
OpenAlexW2083733099

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.