Trial reportPloS one2014
The effect of exercise intensity on endothelial function in physically inactive lean and obese adults.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome
Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Effect of Exercise Prior to Sedentary Behavior on Vascular Health Parameters: A Systematic Review and Meta-Analysis of Crossover Trials.Sports medicine - open · 2024Pooled it
- The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Effects of Glycemic Index and Cereal Fiber on Postprandial Endothelial Function, Glycemia, and Insulinemia in Healthy Adults.Nutrients · 2019Trial
- Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Trial
- The Impact of Obesity on Endothelial Function Following Maximal Aerobic Exercise.International journal of exercise science · 2026Article
- Effects of reducing sedentary behaviour on cardiovascular health, skeletal muscle oxidative capacity and functional exercise capacity in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- The interrelationship among exercise intensity, endothelial function, and ghrelin in healthy humans.Physiological reports · 2025Article
- Extracellular Vesicles in Metabolic and Vascular Insulin Resistance.Journal of vascular research · 2024Review
- Comparison of Hemodynamic and Cerebral Oxygenation Responses during Exercise between Normal-Weight and Overweight Men.Healthcare (Basel, Switzerland) · 2023Article
- Article
- The acute effect of exercise intensity on peripheral and cerebral vascular function in healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study.The international journal of cardiovascular imaging · 2022Observational
- High-intensity exercise in hypoxia improves endothelial function via increased nitric oxide bioavailability in C57BL/6 mice.Acta physiologica (Oxford, England) · 2021Article
- Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals-a pilot study.European journal of applied physiology · 2021Article
- Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.Medicine and science in sports and exercise · 2020Article
- Article
- Article
- Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue.Cardiovascular drugs and therapy · 2019Review
- CrossTalk proposal: Acute exercise elicits damage to the endothelial layer of systemic blood vessels in healthy individuals.The Journal of physiology · 2018Article
- Rebuttal from Volker Adams.The Journal of physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo examine the effects of exercise intensity on acute changes in endothelial function in lean and obese adults.
methodsSixteen lean (BMI <25, age 23 ± 3 yr) and 10 obese (BMI >30, age 26 ± 6 yr) physically inactive adults were studied during 3 randomized admissions [control (C, no exercise), moderate-intensity exercise (M, @ lactate threshold (LT)) and high-intensity exercise (H, midway between LT and VO2peak) (30 min)]. Endothelial function was assessed by flow-mediated dilation (FMD) at baseline and 1, 2, and 4 h post-exercise.
resultsRM ANCOVA revealed significant main effects for group, time, and group x condition interaction (p<0.05). A diurnal increase in FMD was observed in lean but not obese subjects. Lean subjects exhibited greater increases in FMD than obese subjects (p = 0.0005). In the obese group a trend was observed for increases in FMD at 2- and 4-hr after M (p = 0.08). For lean subjects, FMD was significantly elevated at all time points after H. The increase in FMD after H in lean subjects (3.2 ± 0.5%) was greater than after both C (1.7 ± 0.4%, p = 0.015) and M (1.4 ± 0.4%, p = 0.002). FMD responses of lean and obese subjects significantly differed after C and H, but not after M.
conclusionIn lean young adults, high-intensity exercise acutely enhances endothelial function, while moderate-intensity exercise has no significant effect above that seen in the absence of exercise. The FMD response of obese adults is blunted compared to lean adults. Diurnal variation should be considered when examining the effects of acute exercise on FMD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.