Statins × cardiovascular events

SynthesisThe Cochrane database of systematic reviews2014

HMG CoA reductase inhibitors (statins) for kidney transplant recipients.

Suetonia C Palmer et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 3,465 people · 2014

Range includes no effect

No clear effect on cardiovascular events

+14%−6% to +37%

Bigger than 2 in 10 for cardiovascular events

As reported

RR 1.14, 95% CI 0.94–1.37

Range includes no effect

No clear effect on cardiovascular events

−12%−39% to +28%

Bigger than 2 in 10 for cardiovascular events

As reported

RR 0.88, 95% CI 0.61–1.28

Range includes no effect

No clear effect on cardiovascular events

−16%−34% to +6%

Bigger than 3 in 10 for cardiovascular events

As reported

RR 0.84, 95% CI 0.66–1.06

Range includes no effect

No clear effect on cardiovascular events

−32%−55% to +1%

Bigger than 7 in 10 for cardiovascular events

As reported

RR 0.68, 95% CI 0.45–1.01

+6 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

events (1 study, 2102 participants: RR 0.84, CI 0.66 to 1.06), cardiovascular mortality (4 studies, 2322 participants: RR 0.68, CI 0.45 to 1.01), and fatal or non-fatal myocardial infarction (1 study, 2102 participants: RR 0.70, CI 0.48 to 1.01); although effect estimates lack precision and include the possibility of no effect.Statins had uncertain effects on all-cause mortality (6 studies, 2760 participants: RR 1.08, CI 0.63 to 1.83); fatal or non-fatal stroke (1 study, 2102 participants: RR 1.18, CI 0.85 to 1.63); creatine kinase elevation (3 studies, 2233 participants: RR 0.86, CI 0.39 to 1.89); liver enzyme elevation (4 studies, 608 participants: RR 0.62, CI 0.33 to 1.19); withdrawal due to adverse events (9 studies, 2810 participants: RR 0.89, CI 0.74 to 1.06); and cancer

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 1.140.94–1.37
Cardiovascular events
RR 0.880.61–1.28
Cardiovascular events
RR 0.840.66–1.06
Cardiovascular events
RR 0.680.45–1.01
Cardiovascular events
RR 0.700.48–1.01
Cardiovascular events
RR 1.080.63–1.83
Cardiovascular events
RR 1.180.85–1.63
Cardiovascular events
RR 0.860.39–1.89
Cardiovascular events
RR 0.620.33–1.19
Cardiovascular events
RR 0.890.74–1.06
StatinsCardiovascular events

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 24470059