Statins × cardiovascular events

SynthesisBMC cardiovascular disorders2014

Effect of statins on cardiovascular events in patients with mild to moderate chronic kidney disease: a systematic review and meta-analysis of randomized clinical trials.

Xiao Zhang et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 2014

Randomised comparison

Probably reduced cardiovascular events

−34%−48% to −17%

Bigger than 8 in 10 for cardiovascular events

As reported

RR 0.66, 95% CI 0.52–0.83

Not counted

Probably reduced cardiovascular events

−24%−28% to −20%

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.76, 95% CI 0.72–0.80

Not counted

Probably reduced deaths

−21%−28% to −14%

Bigger than 6 in 10 for all-cause mortality

As reported

RR 0.79, 95% CI 0.72–0.86 · the paper's word: All-cause mortality

Not counted

Probably reduced cardiovascular events

−34%−48% to −17%

Bigger than 8 in 10 for cardiovascular events

As reported

RR 0.66, 95% CI 0.52–0.83

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Nine numbers in the abstract

the abstract, start to end

the risk of cardiovascular disease (RR = 0.76,95% confidence interval [CI], 0.72- 0.80), a 21% reduction in the risk of total mortality (RR = 0.79,95% CI, 0.72-0.86), a 34% reduction in the risk of myocardial infarction (RR = 0.66,95% CI, 0.52-0.83), a 30% reduction in the risk of stroke (RR = 0.70,95% CI, 0.57-0.85), and a 17%

patients undergoing stain therapy (RR, 0.79; 95% CI, 0.72-0.86; Figure 3)

a history of cardiovascular disease (RR, 1.48; 95% CI, 0.41-5.36; p = 0.55),

with that of the control treatment was 0.66 (RR, 0.66; 95% CI, 0.52-0.83;

creatinine level ≥1.5 mg/dL (RR, 0.71; 95% CI, 0.45-1.12; p = 0.139;

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 0.760.72–0.80
All-cause mortality
RR 0.790.72–0.86
Cardiovascular events
RR 0.660.52–0.83
Cardiovascular events
RR 0.830.73–0.93
Cardiovascular events
RR 0.700.57–0.85
All-cause mortality
RR 0.790.72–0.86
All-cause mortality
RR 1.480.41–5.36
Cardiovascular events
RR 0.660.52–0.83
Cardiovascular events
RR 0.710.45–1.12
StatinsCardiovascular eventsAll-cause mortality

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours treatmentfavours comparator →
more certainless certain
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