ArticleThe Australasian medical journal2014
Clinical profile of urinary tract infections in diabetics and non-diabetics.
Article in The Australasian medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04735042 (Use of Combination Empagliflozin/Linagliptin or Dapagliflozin/Saxagliptin vs Empagliflozin or Dapagliflozin Alone, Subclinical Inflammation of the Genito-urinary Tract and Risk of Infections.), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Combination Empagliflozin/Linagliptin or Dapagliflozin/Saxagliptin vs Empagliflozin or Dapagliflozin Alone, Subclinical Inflammation of the Genito-urinary Tract and Risk of Infections.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Recurrent Urinary tract infections and type 2 diabetes mellitus: a systematic review predominantly in women.Frontiers in urology · 2023Pooled it
- Type 2 diabetes mellitus and antibiotic-resistant infections: a systematic review and meta-analysis.Journal of epidemiology and community health · 2022Pooled it
- Prevalence, antimicrobial susceptibility patterns of bacterial uropathogens and evaluation of urine dipstick parameter accuracy among individuals with diabetes in Ayder Comprehensive Specialized Hospital and Mekelle General Hospital, Tigray, Ethiopia.BMC infectious diseases · 2026Article
- Distribution and Drug-Resistance Analysis of Uropathogens in Urinary Tract Infections.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Antimicrobial resistance of uropathogens in diabetic patients.BMC infectious diseases · 2025Article
- Association between urinary tract infections and anemia among the elderly in India: Insights from the longitudinal aging study.PLOS global public health · 2025Article
- Characterization of the Phenotypic and Genotypic Antibiotic Resistance Markers inInternational journal of microbiology · 2025Article
- Establishment and validation of a risk prediction model for urinary tract infection in elderly patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Prevalence of Antimicrobial Resistance Among the WHO's AWaRe Classified Antibiotics Used to Treat Urinary Tract Infections in Diabetic Women.Antibiotics (Basel, Switzerland) · 2024Article
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Effect of Diabetes Mellitus on the Spectrum of Uropathogens and the Antimicrobial Resistance in Patients with Urinary Tract Infection.Archives of Razi Institute · 2024Article
- Prevalence and antibiotic resistance profile of UTI-causing uropathogenic bacteria in diabetics and non-diabetics at the Maternity and Children Hospital in Jeddah, Saudi Arabia.Frontiers in microbiology · 2024Article
- Role of Quercetin in DNA Repair: Possible Target to Combat Drug Resistance in Diabetes.Current drug targets · 2024Review
- Common hematological and biochemical parameters for predicting urinary tract infections in geriatric patients with hip fractures.Frontiers in medicine · 2024Article
- Quick Detection ofSensors (Basel, Switzerland) · 2023Article
- Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug-resistant bacterial infection.Clinical case reports · 2023Article
- Article
- The Incidence and Risk Factors of Urinary Tract Infection in Patients with Type 2 Diabetes Mellitus Using SGLT2 Inhibitors: A Real-World Observational Study.Medicines (Basel, Switzerland) · 2022Article
- Urinary tract infection and Diabetes Mellitus-Etio-clinical profile and antibiogram: A North Indian perspective.Journal of family medicine and primary care · 2022Article
- Bacterial uropathogens, their associated factors, and antimicrobial susceptibility pattern among adult diabetic patients in two health centers at Kombolcha town, Northeastern Ethiopia.SAGE open medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of urinary tract infection (UTI) is higher in diabetics compared to non-diabetics. The aetiology and the antibiotic resistance of uropathogens have been changing over the past years. Hence the study was undertaken to determine if there are differences in clinical and microbiological features of UTI between diabetic and non-diabetic subjects, to study the influence of diabetes mellitus on the uropathogens and antibiotic sensitivity pattern in patients with UTI.
methodA total of 181 diabetics (83 males and 98 females) and 124 non-diabetic subjects (52 males and 72 females) with culture positive UTI were studied. Patients with negative urine culture (n= 64), those diagnosed and treated outside (n= 83) and not willing to participate in the study (n= 24) were excluded.
resultsAlmost 30 per cent of the patients (both diabetics and nondiabetics) presented with asymptomatic bacteriuria and the prevalence of pyelonephritis was significantly higher (p= 0.04) in diabetics compared to non-diabetic patients. The majority of the diabetics with UTI (87.14 per cent) had glycosylated haemoglobin (HbA1c) > 6.5 per cent with p < 0.001. The isolation rate of Escherichia coli (E. coli) from urine culture was higher (64.6 per cent) among diabetic patients followed by Klebsiella (12.1 per cent) and Enterococcus (9.9 per cent). The prevalence of extendedspectrum beta-lactamase (ESBL) producing E.coli was significantly higher in diabetics (p= 0.001) compared to nondiabetics. E.coli showed maximum sensitivity to carbapenems in both diabetic and non-diabetic subjects and least susceptibility to ampicillin.
conclusionThe prevalence of pyelonephritis is significantly higher in diabetics than in non-diabetic subjects, with E. coli being the most common isolate. Elevated glycosylated hemoglobin (HbA1c) predisposes diabetics to UTI. Investigation of bacteriuria in diabetic patients for urinary tract infection is important for treatment and prevention of renal complications.
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