ReviewFrontiers in pharmacology2014
Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.
Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease.Biomolecules · 2022Pooled it
- The Portuguese man-of-war genome reveals the genetic basis of medusa loss and sea-air interface adaptation.National science review · 2026Article
- Microinjection of CART peptide into the nucleus accumbens medial shell attenuates methamphetamine-induced anxiety-like behaviors via restoration of GABAScientific reports · 2026Article
- Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations.Molecular metabolism · 2025Article
- GABAMedComm · 2025Review
- Pharmacological mechanism and clinical application of ciprofol.Frontiers in pharmacology · 2025Review
- Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.Frontiers in neuroscience · 2025Review
- Action of GABAThe journal of physiological sciences : JPS · 2024Article
- Review
- Article
- GABA signalling in human pancreatic islets.Frontiers in endocrinology · 2023Review
- Article
- The Presence of Blood-Brain Barrier Modulates the Response to Magnesium Salts in Human Brain Organoids.International journal of molecular sciences · 2022Article
- A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia.Molecular biology reports · 2022Article
- Identification and Validation of Inflammatory Response-Related Gene Signatures to Predict the Prognosis of Neuroblastoma.International journal of genomics · 2022Article
- Mechanisms and Regulation of Neuronal GABACurrent topics in behavioral neurosciences · 2022Review
- The role of GABA in islet function.Frontiers in endocrinology · 2022Review
- Article
- Metabotropic Glutamate Receptors 1 Regulates Rat Carotid Body Response to Acute HypoxiaFrontiers in neuroscience · 2021Article
- Cryo-EM structures of inactive and active GABACell research · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main inhibitory neurotransmitter, GABA, acts on both ligand-gated and G protein-coupled receptors, the GABAA/C and GABAB receptors, respectively. The later play important roles in modulating many synapses, both at the pre- and post-synaptic levels, and are then still considered as interesting targets to treat a number of brain diseases, including addiction. For many years, several subtypes of GABAB receptors were expected, but cloning revealed only two genes that work in concert to generate a single type of GABAB receptor composed of two subunits. Here we will show that the signaling complexity of this unit receptor type can be largely increased through various ways, including receptor stoichiometry, subunit isoforms, cell-surface expression and localization, crosstalk with other receptors, or interacting proteins. These recent data revealed how complexity of a receptor unit can be increased, observation that certainly are not unique to the GABAB receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.