Evidence map›Paper›PMID 24582192›Full record

ArticleMayo Clinic proceedings2014

A pooled analysis of waist circumference and mortality in 650,000 adults.

James R Cerhan, Steven C Moore, Eric J Jacobs, Cari M Kitahara, Philip S Rosenberg, Hans-Olov Adami, Jon O Ebbert, Dallas R English, Susan M Gapstur, Graham G Giles and 11 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mayo Clinic proceedings, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 220 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 10 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03038620 phase4completedstarted 2017, after this paper: background citation

Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease

Ran2017Enrolled235Registered outcomes37Posted comparisons0ConditionsCardiovascular Diseases, Fat Disorder, Obesity, VisceralArmsliraglutide, Placebo
PMID 19853906PMID 21844879PMID 23812094PMID 23850922PMID 25343445PMID 25253227PMID 25190234PMID 24871333PMID 15810802PMID 23687099PMID 25538311PMID 25808071other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 10 syntheses or guidelines pooled it, 427 citations in OpenAlex.

  1. Pooled it
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  6. Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
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160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 5 countries.

James R CerhanDivision of Epidemiology, Mayo Clinic, Rochester, MN. Electronic address: cerhan.james@mayo.edu.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Philip S RosenbergDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Jon O EbbertDivision of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN.
Dallas R EnglishCentre for MEGA Epidemiology, The University of Melbourne, Melbourne, Australia.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Pamela L Horn-RossCancer Prevention Institute of California, Fremont, CA.
Yikyung ParkDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Alpa V PatelEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Kim RobienUniversity of Minnesota School of Public Health, Minneapolis, MN.
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Cancer Register of Norway, Oslo, Norway; Samfundet Folkhälsan, Helsinki, Finland.
Walter C WillettDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Alicja WolkDivision of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, NY.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Leslie BernsteinCity of Hope, Duarte, CA.
Amy Berrington de GonzalezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
American Cancer Society · USDivision of Cancer Epidemiology and GeneticsNational Cancer Institute · USKarolinska Institutet · SEMayo Clinic in Arizona · USCancer Council Victoria · AUCancer Prevention Institute of California · USCity of Hope · USHarvard University · USNew York University · USUiT The Arctic University of Norway · NOUniversity of Melbourne · AUUniversity of Minnesota · US

Funding

PROSPECTIVE STUDY OF DIET AND PROSTATE CANCERP01CA055075 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1991 to 2005
$22.1M
Tumor Immunology (TIM) Research ProgramP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 1985 to 2025
$21.1M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 1985 to 2004
$9.9M
CALIFORNIA TEACHERS STUDYR01CA077398 · UNIVERSITY OF SOUTHERN CALIFORNIA · 1998 to 2005
$9.6M
EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1985 to 2005
$3.6M
Estrogen Metabolites, Related Genes and Breast CancerR01CA098661 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2003 to 2005
$3.0M
Intramural NIH HHSNCI NIH HHS CA77398NCI NIH HHS P01 CA055075NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA39742NIEHS NIH HHS ES000260NIEHS NIH HHS P30 ES000260
6 · The paper itself

Abstract

objectivesTo assess the independent effect of waist circumference on mortality across the entire body mass index (BMI) range and to estimate the loss in life expectancy related to a higher waist circumference. PATIENTS AND

methodsWe pooled data from 11 prospective cohort studies with 650,386 white adults aged 20 to 83 years and enrolled from January 1, 1986, through December 31, 2000. We used proportional hazards regression to estimate hazard ratios (HRs) and 95% CIs for the association of waist circumference with mortality.

resultsDuring a median follow-up of 9 years (maximum, 21 years), 78,268 participants died. After accounting for age, study, BMI, smoking status, alcohol consumption, and physical activity, a strong positive linear association of waist circumference with all-cause mortality was observed for men (HR, 1.52 for waist circumferences of ≥110 vs <90 cm; 95% CI, 1.45-1.59; HR, 1.07 per 5-cm increment in waist circumference; 95% CI, 1.06-1.08) and women (HR, 1.80 for waist circumferences of ≥95 vs <70 cm; 95% CI, 1.70-1.89; HR, 1.09 per 5-cm increment in waist circumference; 95% CI, 1.08-1.09). The estimated decrease in life expectancy for highest vs lowest waist circumference was approximately 3 years for men and approximately 5 years for women. The HR per 5-cm increment in waist circumference was similar for both sexes at all BMI levels from 20 to 50 kg/m(2), but it was higher at younger ages, higher for longer follow-up, and lower among male current smokers. The associations were stronger for heart and respiratory disease mortality than for cancer.

conclusionsIn white adults, higher waist circumference was positively associated with higher mortality at all levels of BMI from 20 to 50 kg/m(2). Waist circumference should be assessed in combination with BMI, even for those in the normal BMI range, as part of risk assessment for obesity-related premature mortality.

Indexed as

Waist CircumferenceAdultAgedAged, 80 and overBody Mass IndexFemaleHumansLife ExpectancyMaleMiddle AgedObesityProportional Hazards ModelsRisk AssessmentRisk FactorsSex FactorsWhite People

Identifiers

PMID24582192
PMCPMC4104704
OpenAlexW2049966070

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.