Evidence map›Paper›PMID 24587337›Full record

Trial reportPloS one2014

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet).

Maria Lankinen, Marjukka Kolehmainen, Tiina Jääskeläinen, Jussi Paananen, Laura Joukamo, Antti J Kangas, Pasi Soininen, Kaisa Poutanen, Hannu Mykkänen, Helena Gylling and 5 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00573781 (Systems Biology Approach to Understand Dietary Modulation of Gene Expression and Metabolic Pathways in Subjects With Abnormal Glucose Metabolism), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00573781 phase2completednot on this map

Systems Biology Approach to Understand Dietary Modulation of Gene Expression and Metabolic Pathways in Subjects With Abnormal Glucose Metabolism (Sysdimet)

TypeinterventionalSponsorMarjukka KolehmainenRan2007 to 2009Enrolled106ConditionsMetabolic Syndrome, Obesity, Impaired Glucose Tolerance, Impaired Fasting GlucoseArmsDiet with increased intake of rye bread, berries and fish, Increased intake of whole grain and rye bread, Control diet with decreased intake of rye bread, berries and fish
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  14. Fish-Derived Omega-3 Fatty Acids: Guardians of High-Density Lipoprotein?Journal of atherosclerosis and thrombosis · 2023
    Article
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  16. Molecules (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Maria LankinenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Marjukka KolehmainenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; VTT, Technical Research Centre of Finland, Kuopio, Finland.
Tiina JääskeläinenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Jussi PaananenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Laura JoukamoDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Antti J KangasComputational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
Pasi SoininenComputational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland ; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Kaisa PoutanenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; VTT, Technical Research Centre of Finland, Espoo, Finland.
Hannu MykkänenDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Helena GyllingDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland.
Matej OrešičVTT, Technical Research Centre of Finland, Espoo, Finland.
Matti JauhiainenNational Institute for Health and Welfare, Public Health Genomics Research Unit, Biomedicum, Helsinki, Finland.
Mika Ala-KorpelaComputational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland ; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland ; Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom ; Oulu University Hospital, Oulu, Finland.
Matti UusitupaDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; Research Unit, Kuopio University Hospital, Kuopio, Finland.
Ursula SchwabDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
University of Eastern Finland · FIKuopio University Hospital · FIUniversity of Bristol · GBUniversity of Oulu · FIVTT Technical Research Centre of Finland · FI

Funding

Medical Research Council MC_UU_12013/1
6 · The paper itself

Abstract

objectiveWe studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome.

methodsAltogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites.

resultsThere were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable.

conclusionsThe results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis.

trial registrationThe study was registered at ClinicalTrials.gov NCT00573781.

Indexed as

DietFish ProductsMetabolomeAdultAgedAnimalsApolipoproteinsCholesterol, HDLEdible GrainFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansLipid MetabolismMaleMetabolic SyndromeApolipoproteinsCholesterol, HDLFatty Acids, Omega-3Fatty Acids, Omega-6

Identifiers

PMID24587337
PMCPMC3938672
OpenAlexW2060832125

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.