ArticleClinica chimica acta; international journal of clinical chemistry2014
LDL cholesterol performance of beta quantification reference measurement procedure.
Article in Clinica chimica acta; international journal of clinical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipid-lowering effect of combined therapy with high-intensity statins and CETP inhibitors: a Systematic Review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement.Journal of lipid research · 2026Article
- Comparison of conventional formulas and machine learning models for estimating serum low-density lipoprotein cholesterol.Practical laboratory medicine · 2026Article
- New Methods for Calculating LDL-Cholesterol and Related Biomarkers of Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2026Review
- Challenges and Future Directions in Lipoprotein Measurement for Atherosclerosis Prevention and Treatment.International journal of molecular sciences · 2024Article
- Obicetrapib-the Rebirth of CETP Inhibitors?Current atherosclerosis reports · 2024Review
- A novel equation for the estimation of low-density lipoprotein cholesterol in the Saudi Arabian population: a derivation and validation study.Scientific reports · 2024Article
- Cardiovascular Risk Assessment and Control in Outpatients Evaluated by 24-hour Ambulatory Blood Pressure and Different LDL-C Equations.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Article
- Development of a Modified Friedewald's Formula to Calculate Low-Density Lipoprotein in an Iranian Population.Iranian journal of medical sciences · 2023Article
- Methods of Low-Density Lipoprotein-Cholesterol Measurement: Analytical and Clinical Applications.EJIFCC · 2022Review
- Comparison of low-density lipoprotein cholesterol level calculated using the modified Martin/Hopkins estimation or the Friedewald formula with direct homogeneous assay measured low-density lipoprotein cholesterol.Archives of medical science : AMS · 2022Article
- Comparison of a Machine Learning Method and Various Equations for Estimating Low-Density Lipoprotein Cholesterol in Korean Populations.Frontiers in cardiovascular medicine · 2022Article
- Detection of Low Density Lipoprotein-Comparison of Electrochemical Immuno- and Aptasensor.Sensors (Basel, Switzerland) · 2021Article
- Comparison of the Japan Society of Clinical Chemistry reference method and CDC method for HDL and LDL cholesterol measurements using fresh sera.Practical laboratory medicine · 2021Article
- Is data mining approach a best fit formula for estimation of low-density lipoprotein cholesterol?Journal of family medicine and primary care · 2021Article
- Comparison of calculated LDL-cholesterol using the Friedewald formula and de Cordova formula with a directly measured LDL-cholesterol in Nepalese population.Practical laboratory medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundAccurate measurement of blood lipids is crucial in cardiovascular disease risk management. The Centers for Disease Control and Prevention (CDC) Cholesterol Reference Method Laboratory Network (CRMLN) has assured the accuracy of these measurements for over 20 years using beta quantification (BQ) method as reference measurement procedure (RMP) for high- and low-density lipoprotein cholesterol (HDL-C, LDL-C). Only limited data exist about the performance of the BQ RMP.
methodsBottom fraction cholesterol (BFC), HDL-C, and LDL-C results after ultracentrifugation from the CDC lipid reference laboratory and the Japanese CRMLN laboratory were compared using 280 serum samples measured over the past 15 years. Data were compared statistically using method comparison and bias estimation analysis.
resultsRegression analysis between CDC (x) and Osaka (y) for BFC, HDL-C, and LDL-C were y=0.988x+1.794 (R(2)=0.997), y=0.980x+1.118 (R(2)=0.994), and y=0.987x+1.200 (R(2)=0.997), respectively. The Osaka laboratory met performance goals for 90% to 95% of the CDC reference values.
conclusionsThe BQ method by the Osaka CRMLN laboratory is highly accurate and has been stable for over 15 years. Accurate measurement of BFC is critical for the determination of LDL-C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.