ArticleJournal of genetic counseling2014
Cancer risk assessment using genetic panel testing: considerations for clinical application.
Article in Journal of genetic counseling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models: The BRIDGE Randomized Clinical Trial.JAMA network open · 2024Trial
- Comparing models of delivery for cancer genetics services among patients receiving primary care who meet criteria for genetic evaluation in two healthcare systems: BRIDGE randomized controlled trial.BMC health services research · 2021Trial
- Understanding how gene-disease relationships can impact clinical utility: adaptations and challenges in hereditary cancer testing.Genome medicine · 2025Article
- Assessment of psychosocial difficulties by genetic clinicians and distress in women at high risk of breast cancer: a prospective study.European journal of human genetics : EJHG · 2022Observational
- Prediction of breast cancer risk based on flow variant analysis of circulating peripheral blood mononuclear cells.HGG advances · 2022Article
- Health care professionals' attitudes toward cancer gene panel testing.The breast journal · 2021Article
- Observational
- Cancer communication research in the era of genomics and precision medicine: a scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Factors Influencing Clinical Follow-Up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Uninformative BRCA1 and BRCA2 Testing.Journal of genetic counseling · 2018Article
- Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Multi-gene panel testing for hereditary cancer susceptibility in a rural Familial Cancer Program.Familial cancer · 2017Observational
- Care delivery considerations for widespread and equitable implementation of inherited cancer predisposition testing.Expert review of molecular diagnostics · 2017Review
- Evaluation of laboratory perspectives on hereditary cancer panels.Familial cancer · 2016Article
- Genetic Counselors' Experiences Regarding Communication of Reproductive Risks with Autosomal Recessive Conditions found on Cancer Panels.Journal of genetic counseling · 2016Article
- Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings.Genetic testing and molecular biomarkers · 2015Article
- Challenges to clinical utilization of hereditary cancer gene panel testing: perspectives from the front lines.Familial cancer · 2015Article
- Availability and payer coverage of BRCA1/2 tests and gene panels.Nature biotechnology · 2015Article
- Article
- Understanding patient and provider perceptions and expectations of genomic medicine.Journal of surgical oncology · 2015Review
- Multigene Panel Testing for Hereditary Cancer Risk.Journal of the advanced practitioner in oncologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.
Indexed as
Identifiers
24599651What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.