ArticleAnnals of the American Thoracic Society2014
Sublingual microcirculation in pulmonary arterial hypertension.
Article in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Treprostinil Iontophoresis in Idiopathic Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2015Trial
- Are transcutaneous oxygen and carbon dioxide determinations of value in pulmonary arterial hypertension?Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Evaluation of Coronary Artery Luminal Diameters in Patients with Pulmonary Arterial Hypertension.Medicina (Kaunas, Lithuania) · 2025Article
- From bench to bedside: A review of the application and potential of microcirculatory assessment by hand-held videomicroscopy.International journal of cardiology. Heart & vasculature · 2024Review
- Sublingual Microcirculation Specificity of Sickle Cell Patients: Morphology of the Microvascular Bed, Blood Rheology, and Local Hemodynamics.International journal of molecular sciences · 2023Article
- Review
- Correlation between Microvascular Damage and Internal Organ Involvement in Scleroderma: Focus on Lung Damage and Endothelial Dysfunction.Diagnostics (Basel, Switzerland) · 2022Review
- Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus.Journal of vascular research · 2022Article
- Impaired endothelium-dependent and endothelium-independent systemic vasodilatory reserve in pulmonary hypertension regardless the clinical group: A generalized dysfunction beyond the pulmonary arteries?Anatolian journal of cardiology · 2021Article
- The Relationship between Pulmonary Damage and Peripheral Vascular Manifestations in Systemic Sclerosis Patients.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Evaluation of Microcirculation, Cytokine Profile, and Local Antioxidant Protection Indices in Periodontal Health, and Stage II, Stage III Periodontitis.Journal of clinical medicine · 2021Article
- Beyond the Lungs: Systemic Manifestations of Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2020Review
- Overview of the Assessment of Endothelial Function in Humans.Frontiers in medicine · 2020Review
- Microvascular involvement in systemic sclerosis and systemic lupus erythematosus.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Functional slit lamp biomicroscopy metrics correlate with cardiovascular risk.The ocular surface · 2019Article
- Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine.Intensive care medicine · 2018Article
- Article
- Novel methods in pulmonary hypertension phenotyping in the age of precision medicine (2015 Grover Conference series).Pulmonary circulation · 2016Review
- A guide to human in vivo microcirculatory flow image analysis.Critical care (London, England) · 2016Article
- Automated Assessment of Hemodynamics in the Conjunctival Microvasculature Network.IEEE transactions on medical imaging · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
rationalePulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that leads to failure of the right ventricle and premature death.
objectivesTo determine whether the sublingual microcirculation is affected in patients with PAH compared with healthy age- and sex-matched control subjects.
methodsUsing the CapiScope Handheld Video Capillaroscope we measured the sublingual microvasculature density, flow index, tortuosity, and curvature. Videos were acquired immediately after right heart catheterization, and determinations were made off-line by investigators blinded to the group assignment or hemodynamics. MEASUREMENTS AND MAIN
resultsIn this cross-sectional pilot study, we included 26 patients with PAH (age, mean ± SD, 56.7 ± 10 yr; 77% women) and 14 healthy control subjects (age, 53.1 ± 12 yr; 71% women). Sublingual microvasculature flow index was lower (2 ± 0.66 vs. 2.7 ± 0.37, P < 0.001) with higher heterogeneity index (0.63 ± 0.63 vs. 0.25 ± 0.25, P = 0.04) in patients with PAH than control subjects. Microvasculature density was similar between the groups, but tortuosity was more pronounced in patients than control subjects (tort 0: 45 ± 19 vs. 23.6 ± 12, P = 0.001 and tort 1: 0.2 ± 0.16 vs. 0.06 ± 0.04, P < 0.001).
conclusionsPatients with PAH showed lower sublingual microvasculature flow index and higher tortuosity compared with healthy age- and sex-matched control subjects. Further investigations are needed to assess whether this methodology can provide information on disease prognosis and/or response to therapy in this condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.