Evidence map›Paper›PMID 24607141›Full record

ArticleStructure (London, England : 1993)2014

How amyloid precursor protein protects itself from cleavage.

Hsiang-Kai Lin, Patrick C A van der Wel

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hsiang-Kai LinDepartment of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.
Patrick C A van der WelDepartment of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA. Electronic address: pvdwel@pitt.edu.

Funding

Structures and Properties of Polyglutamine Proteins and Their AggregatesR01AG019322 · NIA · UNIVERSITY OF TENNESSEE KNOXVILLE · PI WETZEL, RONALD B · 2001 to 2014
$4.6M
NIA NIH HHS R01 AG019322
6 · The paper itself

Abstract

In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.

Indexed as

MutationAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsHumansAmyloid beta-PeptidesAmyloid beta-Protein Precursor

Identifiers

PMID24607141
PMCPMC3996556

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.