Evidence map›Paper›PMID 24621829›Full record

ArticleGenetics2014

Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae.

Li Chen, Kiran Madura

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. A Yeast Mitotic Tale for the Nucleus and the Vacuoles to Embrace.International journal of molecular sciences · 2023
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Nuclear Transport of Yeast Proteasomes.Frontiers in molecular biosciences · 2019
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Protein quality control in the nucleus.Current opinion in cell biology · 2016
    Review
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Li ChenDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey 08854.
Kiran Madura
Johnson University · US

Funding

FUNCTIONAL ANALYSIS OF RAD23 PROTEINR01CA083875 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI MADURA, KIRAN · 2000 to 2016
$4.4M
A Role for Protein Degradation in Nucleotide Excision-RepairR01GM104968 · NIGMS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI MADURA, KIRAN · 2013 to 2016
$1.2M
NCI NIH HHS CA083875NCI NIH HHS R01 CA083875NIGMS NIH HHS GM104968NIGMS NIH HHS R01 GM104968
6 · The paper itself

Abstract

The ubiquitin/proteasome system has been characterized extensively, although the site of nuclear substrate turnover has not been established definitively. We report here that two well-characterized nuclear proteins are stabilized in nuclear export mutants in Saccharomyces cerevisiae. The requirement for nuclear export defines a new regulatory step in intracellular proteolysis.

Indexed as

ProteolysisActive Transport, Cell NucleusCell NucleusCytoplasmDNA-Binding ProteinsDNA Polymerase INuclear ProteinsProteasome Endopeptidase ComplexProtein StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsDNA Polymerase INuclear ProteinsPOL1 protein, S cerevisiaeProteasome Endopeptidase ComplexRad4 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsdegradationexportproteasomesubstrateubiquitin

Identifiers

PMID24621829
PMCPMC4012479
OpenAlexW2121132785

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.