ArticleInternational journal of pharmaceutical investigation2014
Preparation and evaluation of chitosan microspheres containing nicorandil.
Article in International journal of pharmaceutical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate.Heliyon · 2024Article
- Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (ACS omega · 2023Article
- Immobilisation of Cellobiose Dehydrogenase and Laccase on Chitosan Particles as a Multi-Enzymatic System for the Synthesis of Lactobionic Acid.Journal of functional biomaterials · 2023Article
- Extraction, Characterization, and Evaluation ofAdvances in pharmacological and pharmaceutical sciences · 2023Article
- Formulation, characterization and cellular toxicity assessment of a novel bee-venom microsphere in prostate cancer treatment.Scientific reports · 2022Article
- Review
- Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach-A Novel and Potential Antibacterial Formulation.Pharmaceutics · 2020Article
- Preparation of TPP-crosslinked chitosan microparticles by spray drying for the controlled delivery of progesterone intended for estrus synchronization in cattle.Pharmaceutical research · 2018Article
- Drug loaded microbeads entrapped electrospun mat for wound dressing application.Journal of materials science. Materials in medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of present study was to develop chitosan-based sustained release nicorandil microspheres to reduce the dosing frequency. MATERIALS AND
methodsThe nicorandil-loaded chitosan microspheres were formulated by emulsion crosslinking method. A 3(2) factorial design was employed to study the influence of drug: Polymer ratio and volume of glutaraldehyde (GA) on percentage entrapment efficiency, particle size, and % drug release at 8 h.
resultsThe entrapment efficiency was found to be 41.67 ± 1.43-77.33 ± 1.97% and particle size range 65.67 ± 2.08-146.67 ± 2.18 μm. The batch CH5 showed 79.11 ± 2.23 and 96.21 ± 2.41% drug release at 8 and 12 h, respectively.
conclusionsDRUG: Polymer ratio and volume of GA had significant effect on % entrapment efficiency, particle size, and % drug release. From the scanning electron microscopy (SEM) study observed that microspheres were spherical and fairly smooth surface. Fickian diffusion was the mode of drug release from nicorandil-loaded chitosan microspheres formulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.