ArticlePloS one2014
Disruptions in brain networks of older fallers are associated with subsequent cognitive decline: a 12-month prospective exploratory study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Nebulous Association between Cognitive Impairment and Falls in Older Adults: A Systematic Review of the Literature.International journal of environmental research and public health · 2023Pooled it
- Intra-individual variability in cognitive performance predicts falls in older adults with chronic stroke.Aging clinical and experimental research · 2025Trial
- Evidence that intrinsic brain connectivity moderates the association between gait and neurocognitive function in people living with HIV.Journal of neurovirology · 2026Article
- Predicting brain age across the adult lifespan with spontaneous oscillations and functional coupling in resting brain networks captured with magnetoencephalography.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Association of impaired cognitive function with balance confidence, static balance, dynamic balance, functional mobility, and risk of falls in older adults with depression.Aging medicine (Milton (N.S.W)) · 2023Article
- Article
- Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study.Brain sciences · 2021Article
- Sweat the Fall Stuff: Physical Activity Moderates the Association of White Matter Hyperintensities With Falls Risk in Older Adults.Frontiers in human neuroscience · 2021Article
- Postural Control Dysfunction and Balance Rehabilitation in Older Adults with Mild Cognitive Impairment.Brain sciences · 2020Review
- Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors.NeuroImage. Clinical · 2020Article
- Comparison of Functional Connectivity Estimated from Concatenated Task-State Data from Block-Design Paradigm with That of Continuous Task.Computational and mathematical methods in medicine · 2017Article
- The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial.Frontiers in human neuroscience · 2017Article
- Resting State Default Mode Network Connectivity, Dual Task Performance, Gait Speed, and Postural Sway in Older Adults with Mild Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Structural neural correlates of impaired mobility and subsequent decline in executive functions: a 12-month prospective study.Experimental gerontology · 2016Article
- Differences in Resting State Functional Connectivity between Young Adult Endurance Athletes and Healthy Controls.Frontiers in human neuroscience · 2016Article
- The Neurocognitive Basis for Impaired Dual-Task Performance in Senior Fallers.Frontiers in aging neuroscience · 2016Article
- Insight and psychosis: Functional and anatomical brain connectivity and self-reflection in Schizophrenia.Human brain mapping · 2015Article
- Elevated body mass index and maintenance of cognitive function in late life: exploring underlying neural mechanisms.Frontiers in aging neuroscience · 2015Article
- Article
- The role of postural instability/gait difficulty and fear of falling in predicting falls in non-demented older adults.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Cognitive impairment and impaired mobility are major public health concerns. There is growing recognition that impaired mobility is an early biomarker of cognitive impairment and dementia. The neural basis for this association is currently unclear. We propose disrupted functional connectivity as a potential mechanism. In this 12-month prospective exploratory study, we compared functional connectivity of four brain networks- the default mode network (DMN), fronto-executive network (FEN), fronto-parietal network (FPN), and the primary motor sensory network (SMN)--between community-dwelling older adults with ≥ two falls in the last 12 months and their non-falling counterparts (≤ one fall in the last 12 months). Functional connectivity was examined both at rest and during a simple motor tapping task. Compared with non-fallers, fallers showed more connectivity between the DMN and FPN during right finger tapping (p = 0.04), and significantly less functional connectivity between the SMN and FPN during rest (p ≤ 0.05). Less connectivity between the SMN and FPN during rest was significantly associated with greater decline in both cognitive function and mobility over the12-month period (r = -0.32 and 0.33 respectively; p ≤ 0.04). Thus, a recent history of multiple falls among older adults without a diagnosis of dementia may indicate sub-clinical changes in brain function and increased risk for subsequent decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.