ArticleMethods (San Diego, Calif.)2014
Tools and methods for studying Notch signaling in Drosophila melanogaster.
Article in Methods (San Diego, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Notch is a ligand of Draper mediating spermatogonia cell death.Nature communications · 2026Article
- A Notch signal required for a morphological novelty inScience advances · 2025Article
- The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling.The Journal of cell biology · 2025Article
- Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila.Nature communications · 2025Article
- Article
- Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo.The Journal of cell biology · 2023Article
- A mechanosensitive vascular niche forProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Notch signaling pathway in skeletal muscle health and disease.Muscle & nerve · 2022Review
- A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects.PLoS genetics · 2022Article
- SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo.Developmental cell · 2022Article
- Article
- The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity inBiomolecules · 2021Article
- Review
- Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.PLoS genetics · 2021Article
- A cell atlas of adult muscle precursors uncovers early events in fibre-type divergence in Drosophila.EMBO reports · 2020Article
- Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration ineLife · 2020Article
- Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity.Developmental neurobiology · 2020Article
- Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.Scientific reports · 2019Article
- Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila.The EMBO journal · 2019Article
- NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer.Oncology letters · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Notch signaling involves a highly conserved pathway that mediates communication between neighboring cells. Activation of Notch by its ligands, results in the release of the Notch intracellular domain (NICD), which enters the nucleus and regulates transcription. This pathway has been implicated in many developmental decisions and diseases (including cancers) over the past decades. The simplicity of the Notch pathway in Drosophila melanogaster, in combination with the availability of powerful genetics, make this an attractive model for studying fundamental principles of Notch regulation and function. In this article we present some of the established and emerging tools that are available to monitor and manipulate the Notch pathway in Drosophila and discuss their strengths and weaknesses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.