Evidence map›Paper›PMID 24705609›Full record

ArticleDiabetes care2014

Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996-2010.

Denice S Feig, Jeremiah Hwee, Baiju R Shah, Giliian L Booth, Arlene S Bierman, Lorraine L Lipscombe

2 registry-linked trialsOpen access · hybridAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 136 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 9 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05479214 phase4completedstarted 2022, after this paper: background citation

Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy on Glycemic Control, Fetal and Neonatal Outcomes ,Randomized Controlled Trial

Ran2022Enrolled150Registered outcomes8Posted comparisons0ConditionsDiabetes Mellitus PregnancyArmsInsulin, Metformin
PMID 24847880PMID 25874236PMID 18297573PMID 17336651PMID 28761217PMID 27549587PMID 21843303PMID 9203460PMID 28217599other papers from this trial
Open the trial in the graph
NCT04902378 nacompletednot on this mapstarted 2021, after this paper: background citation

Closed-loop Insulin Delivery by Glucose Responsive Computer Algorithms In Type 1 Diabetes Pregnancies (CIRCUIT)

TypeinterventionalSponsorUniversity of CalgaryRan2021 to 2025Enrolled94ConditionsType 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic DiseaseArmsTandem t:slim X2 insulin pump with Control IQ technology
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 9 syntheses or guidelines pooled it, 347 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Guidelines for the management of pregnant women with obesity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Denice S FeigDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaInstitute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaDepartment of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, CanadaDivision of Endocrinology and Metabolism, Mount Sinai Hospital, Toronto, Ontario, Canada d.feig@utoronto.ca.
Jeremiah HweeInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Baiju R ShahDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaInstitute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaDivision of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Giliian L BoothDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaInstitute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, CanadaDivision of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada.
Arlene S BiermanDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaInstitute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, CanadaDivision of Internal Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
Lorraine L LipscombeDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaInstitute for Clinical Evaluative Sciences, Toronto, Ontario, CanadaWomen's College Research Institute and the Division of Endocrinology and Metabolism, Women's College Hospital, Toronto, Ontario, Canada.
Institute for Clinical Evaluative Sciences · CAHealth Sciences Centre · CASt. Michael's Hospital · CAUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

objectiveWomen with diabetes in pregnancy have high rates of pregnancy complications. Our aims were to explore trends in the incidence of diabetes in pregnancy and examine whether the risk of serious perinatal outcomes has changed. RESEARCH DESIGN AND

methodsWe performed a population-based cohort study of 1,109,605 women who delivered in Ontario, Canada, between 1 April 1996 and 31 March 2010. We categorized women as gestational diabetes (GDM) (n = 45,384), pregestational diabetes (pre-GDM) (n = 13,278), or no diabetes (n = 1,050,943). The annual age-adjusted rates of diabetes in pregnancy were calculated, and rates of serious perinatal outcomes were compared between groups and by year using Poisson regression.

resultsThe age-adjusted rate of both GDM (2.7-5.6%, P < 0.001) and pre-GDM (0.7-1.5%, P < 0.001) doubled from 1996 to 2010. The rate of congenital anomalies declined by 23%, whereas the rate of perinatal mortality did not change significantly. However, compared with women with no diabetes, women with pre-GDM and GDM faced an increased risk of congenital anomalies (relative risk 1.86 [95% CI 1.49-2.33] and 1.26 [1.09-1.45], respectively), and perinatal mortality remained elevated in women with pre-GDM (2.33 [1.59-3.43]).

conclusionsThe incidence of both GDM and pre-GDM in pregnancy has doubled over the last 14 years, and the overall burden of diabetes in pregnancy on society is growing. Although congenital anomaly rates have declined in women with diabetes, perinatal mortality rates remain unchanged, and the risk of both remains significantly elevated compared with nondiabetic women. Increased efforts are needed to reduce these adverse outcomes.

Indexed as

AdolescentAdultCanadaCase-Control StudiesCohort StudiesCongenital AbnormalitiesDiabetes, GestationalFemaleHumansIncidenceInfant, NewbornMiddle AgedPerinatal MortalityPregnancyPregnancy ComplicationsPregnancy Outcome

Identifiers

PMID24705609
OpenAlexW2031038320

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.