Evidence map›Paper›PMID 24705678›Full record

Trial reportLung2014

Exercise limitation in IPF patients: a randomized trial of pulmonary rehabilitation.

Robert M Jackson, Orlando W Gómez-Marín, Carol F Ramos, Constanza M Sol, Meryl I Cohen, Ignacio A Gaunaurd, Lawrence P Cahalin, Diana D Cardenas

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01118221 (Rehabilitation of IPF Patients), which is not on this map. Cited by 41 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 8 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01118221 nacompletednot on this map

Rehabilitation of IPF Patients: Effects of Exercise and Oxidant Stress

TypeinterventionalSponsorUS Department of Veterans AffairsRan2010 to 2013Enrolled25ConditionsIdiopathic Pulmonary FibrosisArmspulmonary rehabilitation
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 8 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  6. Pulmonary rehabilitation for interstitial lung disease.The Cochrane database of systematic reviews · 2021
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  17. Self-management interventions for people with pulmonary fibrosis: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Robert M JacksonResearch Service (151), Miami VAHS, 1201 NW 16th Street, Miami, FL, 33125, USA, rjackson2@med.miami.edu.
Orlando W Gómez-Marín
Carol F Ramos
Constanza M Sol
Meryl I Cohen
Ignacio A Gaunaurd
Lawrence P Cahalin
Diana D Cardenas
University of Miami · USMiami VA Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with idiopathic pulmonary fibrosis (IPF) have severely limited exercise capacity due to dyspnea, hypoxemia, and abnormal lung mechanics. This pilot study was designed to determine whether pulmonary rehabilitation were efficacious in improving the 6-min walk test (6-MWT) distance, exercise oxygen uptake, respiratory muscle strength [maximum inspiratory pressure (MIP)], and dyspnea in patients with IPF. Underlying physiological mechanisms and effects of the intervention were investigated.

methodsSubjects were randomly assigned to a 3-month pulmonary rehabilitation program (n = 11) or to a control group (n = 10). All subjects initially underwent the 6-MWT and constant load exercise gas exchange studies.

resultsSubjects in the rehabilitation group increased treadmill exercise [metabolic equivalent of task-minutes] over the first 14 sessions. Beneficial effects on physical function resulted in those who completed rehabilitation. Subjects who completed the program increased cycle ergometer time and maintained exercise oxygen consumption (exercise VO(2)) at the baseline level over 3 months, while the control group suffered a significant decrease in exercise VO(2). Rehabilitation subjects also increased their MIP. Plasma lactate doubled and brain natriuretic peptide levels increased significantly after exercise, as did the plasma amino acids glutamic acid, arginine, histidine, and methionine. These changes were associated with significant decreases in arterial oxygen saturation and increases in 15-F(2t)-isoprostanes after exercise.

conclusionsPulmonary rehabilitation effectively maintained exercise oxygen uptake over 3 months and lengthened constant load exercise time in patients with moderately severe IPF. Exercise endurance on cycle ergometry testing was limited by dyspnea and severe hypoxemia associated with systemic oxidant stress.

Indexed as

Exercise TherapyExercise ToleranceOxygen Inhalation TherapyAgedBiomarkersDyspneaExercise TestFloridaHumansHypoxiaIdiopathic Pulmonary FibrosisLungMiddle AgedMuscle StrengthOxygen ConsumptionPilot ProjectsBiomarkers

Identifiers

PMID24705678
OpenAlexW1973615532

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.