Evidence map›Paper›PMID 24738668›Full record

ArticleThe New England journal of medicine2014

Changes in diabetes-related complications in the United States, 1990-2010.

Edward W Gregg, Yanfeng Li, Jing Wang, Nilka Rios Burrows, Mohammed K Ali, Deborah Rolka, Desmond E Williams, Linda Geiss

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04271189 (A Prospective, Randomized, Parallel-group, Adaptive Design Phase IIb/III, Multicenter Study, to Assess the Efficacy of Polychemotherapy for Inducing Remission of Newly Diagnosed Type 2 Diabetes.), which is not on this map. Cited by 760 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
760citing papers in PubMed, 8 pooled it
120.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04271189 phase3completedstarted 2020, after this paper: background citation

A Prospective, Randomized, Parallel-group, Adaptive Design Phase IIb/III, Multicenter Study, to Assess the Efficacy of Polychemotherapy for Inducing Remission of Newly Diagnosed Type 2 Diabetes.

Ran2020Enrolled108Registered outcomes10Posted comparisons0ConditionsNewly Diagnosed Type 2 DiabetesArmsMetformin-Sitagliptin-Empaglifozin-Pioglitazone, Standard of care
PMID 17914032PMID 23116881PMID 26138864PMID 24463454PMID 11832527PMID 23354123PMID 26868433PMID 26696678PMID 26670418PMID 26378978PMID 24315620PMID 34462270other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

760 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,718 citations in OpenAlex.

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  7. Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2023
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  15. Trends in cardiometabolic disease and health-related quality of life in the United States, 2001-2022.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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700 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Edward W GreggFrom the Division of Diabetes Translation, Centers for Disease Control and Prevention (E.W.G., Y.L., J.W., N.R.B., M.K.A., D.R., D.E.W., L.G.), and the Rollins School of Public Health, Emory University (M.K.A.) - both in Atlanta.
Yanfeng Li
Jing Wang
Nilka Rios Burrows
Mohammed K Ali
Deborah Rolka
Desmond E Williams
Linda Geiss
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreventive care for adults with diabetes has improved substantially in recent decades. We examined trends in the incidence of diabetes-related complications in the United States from 1990 through 2010.

methodsWe used data from the National Health Interview Survey, the National Hospital Discharge Survey, the U.S. Renal Data System, and the U.S. National Vital Statistics System to compare the incidences of lower-extremity amputation, end-stage renal disease, acute myocardial infarction, stroke, and death from hyperglycemic crisis between 1990 and 2010, with age standardized to the U.S. population in the year 2000.

resultsRates of all five complications declined between 1990 and 2010, with the largest relative declines in acute myocardial infarction (-67.8%; 95% confidence interval [CI], -76.2 to -59.3) and death from hyperglycemic crisis (-64.4%; 95% CI, -68.0 to -60.9), followed by stroke and amputations, which each declined by approximately half (-52.7% and -51.4%, respectively); the smallest decline was in end-stage renal disease (-28.3%; 95% CI, -34.6 to -21.6). The greatest absolute decline was in the number of cases of acute myocardial infarction (95.6 fewer cases per 10,000 persons; 95% CI, 76.6 to 114.6), and the smallest absolute decline was in the number of deaths from hyperglycemic crisis (-2.7; 95% CI, -2.4 to -3.0). Rate reductions were larger among adults with diabetes than among adults without diabetes, leading to a reduction in the relative risk of complications associated with diabetes. When expressed as rates for the overall population, in which a change in prevalence also affects complication rates, there was a decline in rates of acute myocardial infarction and death from hyperglycemic crisis (2.7 and 0.1 fewer cases per 10,000, respectively) but not in rates of amputation, stroke, or end-stage renal disease.

conclusionsRates of diabetes-related complications have declined substantially in the past two decades, but a large burden of disease persists because of the continued increase in the prevalence of diabetes. (Funded by the Centers for Disease Control and Prevention.).

Indexed as

AdultAmputation, SurgicalDiabetes ComplicationsHealth SurveysHumansHyperglycemiaIncidenceKidney Failure, ChronicMyocardial InfarctionStrokeUnited States

Identifiers

PMID24738668
OpenAlexW2147222003

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.