Evidence map›Paper›PMID 24739435›Full record

ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2014

Genetic psychophysiology: advances, problems, and future directions.

Andrey P Anokhin

Abstract readReview
In one paragraph

Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Biomarkers of Obsessive-Compulsive Disorder Subtypes: A Literature Review.International journal of molecular sciences · 2025
    Review
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  18. Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Article
  19. A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
  20. Heritability of brain activity related to response inhibition: A longitudinal genetic study in adolescent twins.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Andrey P AnokhinWashington University School of Medicine, Department of Psychiatry, 660 S. Euclid, Box 8134, St. Louis, MO 63110, United States. Electronic address: andrey@wustl.edu.

Funding

NEUROCOGNITION, GENETICS, AND ADOLESCENT SUBSTANCE ABUSER01DA018899 · NIDA · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2004 to 2015
$4.9M
College Drinking: A Twin StudyR01AA013989 · NIAAA · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2002 to 2006
$2.5M
Linking Genetics, Brain, and Behavior to Understand Addiiction VulnerabilityK02DA027096 · NIDA · WASHINGTON UNIVERSITY · PI ANOKHIN, ANDREY P. · 2009 to 2013
$559k
NIAAA NIH HHS R01 AA013989NIDA NIH HHS DA01889NIDA NIH HHS DA027096NIDA NIH HHS K02 DA027096NIDA NIH HHS R01 DA018899
6 · The paper itself

Abstract

This paper presents an overview of historical advances and the current state of genetic psychophysiology, a rapidly developing interdisciplinary research linking genetics, brain, and human behavior, discusses methodological problems, and outlines future directions of research. The main goals of genetic psychophysiology are to elucidate the neural pathways and mechanisms mediating genetic influences on cognition and emotion, identify intermediate brain-based phenotypes for psychopathology, and provide a functional characterization of genes being discovered by large association studies of behavioral phenotypes. Since the initiation of this neurogenetic approach to human individual differences in the 1970s, numerous twin and family studies have provided strong evidence for heritability of diverse aspects of brain function including resting-state brain oscillations, functional connectivity, and event-related neural activity in a variety of cognitive and emotion processing tasks, as well as peripheral psychophysiological responses. These data indicate large differences in the presence and strength of genetic influences across measures and domains, permitting the selection of heritable characteristics for gene finding studies. More recently, candidate gene association studies began to implicate specific genetic variants in different aspects of neurocognition. However, great caution is needed in pursuing this line of research due to its demonstrated proneness to generate false-positive findings. Recent developments in methods for physiological signal analysis, hemodynamic imaging, and genomic technologies offer new exciting opportunities for the investigation of the interplay between genetic and environmental factors in the development of individual differences in behavior, both normal and abnormal.

Indexed as

GeneticsPsychophysiologyBrainBrain WavesGenetic LinkageHumansTwin Studies as TopicBrainEEGEndophenotypeERPGeneticsHeritability

Identifiers

PMID24739435
PMCPMC4077936

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.