Evidence map›Paper›PMID 24755906›Full record

Trial reportPloS one2014

Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study.

Saloua El Messaoudi, Tim H Schreuder, Roel D Kengen, Gerard A Rongen, Petra H van den Broek, Dick H J Thijssen, Niels P Riksen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01610401 (Can Metformin Prevent Endothelial Ischemia and Reperfusion Injury? The Metformin-FMD Trial), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01610401 phase4completednot on this map

Can Metformin Prevent Endothelial Ischemia and Reperfusion Injury? The Metformin-FMD Trial

TypeinterventionalSponsorRadboud University Medical CenterRan2012 to 2013Enrolled26ConditionsIschemia Reperfusion Injury, Endothelial FunctionArmsMetformin, Pretreatment with metformin in combination of infusion of caffeine., No pretreatment with metformin in combination with infusion of caffeine
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Saloua El MessaoudiDepartment of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tim H SchreuderDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Roel D KengenDepartment of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.
Gerard A RongenDepartment of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Petra H van den BroekDepartment of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.
Dick H J ThijssenDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands; Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Niels P RiksenDepartment of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NLLiverpool John Moores University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLarge prospective studies in patients with type 2 diabetes mellitus have demonstrated that metformin treatment improves cardiovascular prognosis, independent of glycemic control. Administration of metformin potently limits infarct size in murine models of myocardial infarction. This study examined, for the first time in humans, whether metformin limits ischemia-reperfusion (IR) injury in vivo using a well-validated forearm model of endothelial IR-injury.

methodsTwenty-eight healthy volunteers (age 41±6 years, 10 male/16 female) were randomized between pretreatment with metformin (500 mg three times a day for 3 days) or no treatment in a Prospective Randomized Open Blinded Endpoint study. Brachial artery flow mediated dilation (FMD) was measured before and after 20 minutes of forearm ischemia and 20 minutes of reperfusion. FMD analysis was performed offline by investigators blinded for the treatment arm.

resultsBaseline FMD did not differ between metformin pretreatment and no pretreatment (6.9±3.6% and 6.1±3.5%, respectively, p = 0.27, n = 26). FMD was significantly lower after forearm IR in both treatment arms (4.4±3.3% and 4.3±2.8%, respectively, P<0.001 in both conditions). A linear mixed model analysis revealed that metformin treatment did not prevent the decrease in FMD by IR.

conclusionA 3 day treatment with metformin in healthy, middle-aged subjects does not protect against endothelial IR-injury, measured with brachial artery FMD after forearm ischemia. Further studies are needed to clarify what mechanism underlies the cardiovascular benefit of metformin treatment.

trial registrationClinicalTrials.gov NCT01610401.

Indexed as

AdultBrachial ArteryEndothelium, VascularFemaleForearmHumansHypoglycemic AgentsMaleMetforminMiddle AgedProspective StudiesRegional Blood FlowReperfusion InjurySingle-Blind MethodHypoglycemic AgentsMetformin

Identifiers

PMID24755906
PMCPMC3996005
OpenAlexW2003072700

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.