ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Dysregulation of noncoding RNA in chordoma; implications in identifying potential targets for novel therapeutic approaches.Molecular biology reports · 2024Review
- LncRNA NONHSAT114552 Sponges miR-320d to Promote Proliferation and Invasion of Chordoma Through Upregulating NRP1.Frontiers in pharmacology · 2021Article
- Development and Validation of a 6-miRNA Prognostic Signature in Spinal Chordoma.Frontiers in oncology · 2020Article
- Clinicopathological implications of TIM3Cancer immunology, immunotherapy : CII · 2019Article
- miR-1290 inhibits chordoma cell proliferation and invasion by targeting Robo1.Translational cancer research · 2019Article
- miR-1-3p suppresses the epithelial-mesenchymal transition property in renal cell cancer by downregulating Fibronectin 1.Cancer management and research · 2019Article
- Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3.OncoTargets and therapy · 2019Article
- miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3.Cell death & disease · 2018Article
- A giant lumbar chordoma: A case report.Medicine · 2018Article
- Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Low expression of miRNA-1290 associated with local invasion and recurrence in sacral chordoma.International journal of clinical and experimental pathology · 2017Article
- miR-219-5p inhibits proliferation and clonogenicity in chordoma cells and is associated with tumor recurrence.Oncology letters · 2016Article
- The roles of microRNAs related with progression and metastasis in human cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential.Oncotarget · 2016Article
- miR-497 inhibits epithelial mesenchymal transition in breast carcinoma by targeting Slug.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Computer Navigation-aided Resection of Sacral Chordomas.Chinese medical journal · 2016Article
- Recent advances in understanding and managing chordomas.F1000Research · 2016Review
- Chordoma: The Quest for Better Treatment Options.Oncology and therapy · 2016Review
- Epigenetic deregulations in chordoma.Cell proliferation · 2015Review
- MicroRNAs in the pathobiology of sarcomas.Laboratory investigation; a journal of technical methods and pathology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have revealed that expression of miRNA-1 (miR-1) is frequently down-regulated in several cancer types including chordoma. Identifying and validating novel targets of miR-1 is useful for understanding the roles of miR-1 in chordoma. We aimed to further investigate the functions of miR-1 in chordoma. Specifically, we assessed whether restoration of miR-1 affects cell migration and invasion in chordoma, and focused on the miR-1 potential target Slug gene. Migratory and invasive activities were assessed by wound healing and Matrigel invasion assays, respectively. Cell proliferation was determined by MTT assay. Slug expression was evaluated by Western blot, immunofluorescence, and immunohistochemistry. Restoration of miR-1 expression suppressed the migratory and invasive activities of chordoma cells. Transfection of miR-1 inhibited cell proliferation both time- and dose-dependently in chordoma. MiR-1 transfected cells showed inhibited Slug expression. Slug was over-expressed in chordoma cell lines and advanced chordoma tissues. In conclusion, we have shown that miR-1 directly targets the Slug gene in chordoma. Restoration of miR-1 suppressed not only proliferation, but also migratory and invasive activities, and reduced the Slug expression in chordoma cells. These results collectively indicate that miR-1/Slug pathway is a potential therapeutic target because of its crucial roles in chordoma cell growth and migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.