Evidence mapPaperPMID 24778463Full record

ReviewDisease markers2014

Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells.

Olivia Torres-Bugarín, María Guadalupe Zavala-Cerna, Arnulfo Nava, Aurelio Flores-García, María Luisa Ramos-Ibarra

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03848533 phase2unknown statusstarted 2019, after this paper: background citation

Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study

Ran2019Enrolled42Registered outcomes19Posted comparisons0ConditionsPrediabetesArmsMelatonin, Metformin, Placebo
Open the trial in the graph
NCT04460755 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells

TypeinterventionalSponsorUniversity of ZagrebRan2019 to 2020Enrolled210ConditionsTeeth WhiteningArmsControl group, Whitening toothpaste 1, Whitening toothpaste 2, Whitening toothpaste 3, Whitening toothpaste 4
NCT05712044 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluation of the Effect of Folic Acid Supplementation on the Presentation of Nuclear Abnormalities Associated With Cytogenotoxic Damage Induced by Chronic Drug Use.

TypeinterventionalSponsorCentro Universitario de TonaláRan2023 to 2023Enrolled45ConditionsDrug Abuse, GenotoxicityArmsFolic Acid 5 MG
3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Artisanal Gem Mining in Brazil: A Source of Genotoxicity and Exposure to Toxic Elements.International journal of environmental research and public health · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Cytogenetic Biomonitoring on Oral Mucosa Cells of Hookah Users: Is It Possible?Asian Pacific journal of cancer prevention : APJCP · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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  19. Silver ciprofloxacin (CIPAG): a successful combination of chemically modified antibiotic in inorganic-organic hybrid.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olivia Torres-BugarínPrograma Internacional, Facultad de Medicina, Universidad Autónoma de Guadalajara, 45129 Zapopan, JAL, Mexico.
María Guadalupe Zavala-CernaPrograma Internacional, Facultad de Medicina, Universidad Autónoma de Guadalajara, 45129 Zapopan, JAL, Mexico.
Arnulfo NavaPrograma Internacional, Facultad de Medicina, Universidad Autónoma de Guadalajara, 45129 Zapopan, JAL, Mexico ; Unidad de Investigación en Epidemiología Clínica, UMAE, HE, CMNO, IMSS, Guadalajara, JAL, Mexico ; Servicio de Medicina Interna, Reumatología e Inmunología Hospital General de Occidente SSJ, Zapopan, JAL, Mexico.
Aurelio Flores-GarcíaUnidad Académica de Medicina, Universidad Autónoma de Nayarit, 63155 Tepic, NAY, Mexico.
María Luisa Ramos-IbarraDivisión de Ciencias Veterinarias, Departamento Salud Pública, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, 45221 Zapopan, JAL, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of biomarkers as tools to evaluate genotoxicity is increasing recently. Methods that have been used previously to evaluate genomic instability are frequently expensive, complicated, and invasive. The micronuclei (MN) and nuclear abnormalities (NA) technique in buccal cells offers a great opportunity to evaluate in a clear and precise way the appearance of genetic damage whether it is present as a consequence of occupational or environmental risk. This technique is reliable, fast, relatively simple, cheap, and minimally invasive and causes no pain. So, it is well accepted by patients; it can also be used to assess the genotoxic effect derived from drug use or as a result of having a chronic disease. Furthermore the beneficial effects derived from changes in life style or taking additional supplements can also be evaluated. In the present paper, we aim to focus on the explanation of MN test and its usefulness as a biomarker; we further give details about procedures to perform and interpret the results of the test and review some factors that could have an influence on the results of the technique.

Indexed as

DNA DamageMicronuclei, Chromosome-DefectiveAnimalsBiomarkersCell NucleusCytodiagnosisHumansMicronucleus TestsMouth MucosaBiomarkers

Identifiers

PMID24778463
PMCPMC3932264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.