Evidence map›Paper›PMID 24846275›Full record

SynthesisBMJ (Clinical research ed.)2014

Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials.

Alexander C Ford, David Forman, Richard H Hunt, Yuhong Yuan, Paul Moayyedi

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 278 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
278citing papers in PubMed, 17 pooled it
51.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

278 citing papers in PubMed, 17 syntheses or guidelines pooled it, 590 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. The effect of supplementing withFrontiers in medicine · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Helicobacter pylori eradication for the prevention of gastric neoplasia.The Cochrane database of systematic reviews · 2020
    Pooled it
  8. Pooled it
  9. Pooled it
  10. BMJ open · 2019
    Pooled it
  11. Guideline
  12. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019
    Pooled it
  13. Pooled it
  14. Simulation Models in Gastric Cancer Screening: A Systematic ReviewAsian Pacific journal of cancer prevention : APJCP · 2018
    Pooled it
  15. Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018
    Pooled it
  16. Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

218 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Alexander C FordLeeds Gastroenterology Institute, St James's University Hospital, Leeds LS9 7TF, UK Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK alexf12399@yahoo.com.
David FormanCancer Information Section, International Agency for Research on Cancer, Lyon, France.
Richard H HuntFarncombe Family Digestive Health Research Institute, Gastroenterology Division, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
Yuhong YuanFarncombe Family Digestive Health Research Institute, Gastroenterology Division, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
Paul MoayyediFarncombe Family Digestive Health Research Institute, Gastroenterology Division, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
Population Health Research Institute · CACentre International de Recherche sur le Cancer · FRUniversity of Leeds · GB

Funding

World Health Organization 001
6 · The paper itself

Abstract

objectivesTo determine whether searching for Helicobacter pylori and treating with eradication therapy leads to a reduction in incidence of gastric cancer among healthy asymptomatic infected individuals.

designSystematic review and meta-analysis of randomised controlled trials. DATA SOURCES: Medline, Embase, and the Cochrane central register of controlled trials were searched through to December 2013. Conference proceedings between 2001 and 2013 were hand searched. A recursive search was performed with bibliographies of relevant studies. There were no language restrictions. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials examining the effect of at least seven days of eradication therapy on subsequent occurrence of gastric cancer in adults who tested positive for Helicobacter pylori but otherwise healthy and asymptomatic were eligible. The control arm had to receive placebo or no treatment. Subjects had to be followed for ≥ 2 years.

main outcome measuresPrimary outcome, defined a priori, was the effect of eradication therapy on the subsequent occurrence of gastric cancer expressed as a relative risk of gastric cancer with 95% confidence intervals.

resultsThe search strategy identified 1560 citations, of which six individual randomised controlled trials were eligible. Fifty one (1.6%) gastric cancers occurred among 3294 individuals who received eradication therapy versus 76 (2.4%) in 3203 control subjects (relative risk 0.66, 95% confidence interval 0.46 to 0.95), with no heterogeneity between studies (I(2)=0%, P=0.60). If the benefit of eradication therapy was assumed to persist lifelong the number needed to treat was as low as 15 for Chinese men and as high as 245 for US women.

conclusionsThese data provide limited, moderate quality evidence that searching for and eradicating H pylori reduces the incidence of gastric cancer in healthy asymptomatic infected Asian individuals, but these data cannot necessarily be extrapolated to other populations.

Indexed as

Asymptomatic InfectionsDisease EradicationHelicobacter pyloriHelicobacter InfectionsHumansOutcome and Process Assessment, Health CareRandomized Controlled Trials as TopicStomach Neoplasms

Identifiers

PMID24846275
PMCPMC4027797
OpenAlexW2139464969

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.