SynthesisEndocrine2014
Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials.
Synthesis in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies.Diabetes & metabolism journal · 2019Pooled it
- Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies.BMJ (Clinical research ed.) · 2019Pooled it
- Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing.Oxidative medicine and cellular longevity · 2015Pooled it
- Trial
- Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes.Journal of the National Cancer Institute · 2016Trial
- Association of Dietary Selenium Intake with Type 2 Diabetes in Middle-Aged and Older Adults in China.Nutrients · 2024Article
- Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Review
- The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities.Redox biology · 2022Review
- Changes of trace element status during aging: results of the EPIC-Potsdam cohort study.European journal of nutrition · 2020Article
- Use and abuse of dietary supplements in persons with diabetes.Nutrition & diabetes · 2020Review
- Influence of selenium supplementation on carbohydrate metabolism and oxidative stress in pregnant women with gestational diabetes mellitus.Journal of medical biochemistry · 2020Article
- The Association of Circulating Selenium Concentrations with Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study.Redox biology · 2017Article
- High dietary selenium intake is associated with less insulin resistance in the Newfoundland population.PloS one · 2017Article
- Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study.Nutrients · 2016Article
- Selenium: an element for life.Endocrine · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well documented that selenium (Se) is involved in the metabolism of glucose. However, whether Se supplementation could lower the risk of type 2 diabetes mellitus (T2DM) remains elusive. We aimed to evaluate the association between Se supplementation and the risk of T2DM by performing a meta-analysis. We searched the Pubmed, Embase, and Cochrane databases from January 1990 to November 2013 to identify randomized controlled trials (RCTs) that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the pooled prevention effects. Four RCTs involving 20,294 participants were included in this meta-analysis. The combined relative risks (RRs) for subjects administered with Se compared with control groups were 1.09 (95 % CI: 0.99-1.20, p = 0.085). Omission of any single study did not change the overall risk estimates significantly. Meta- regression analyses showed almost no impact on the RRs of age and study length. No evidence of publication bias was observed. In conclusion, our findings do not support the routine application of Se supplementation for T2DM prevention in Caucasians. Larger studies are needed to investigate the effects of Se supplementation on T2DM prevention among various populations and further elucidate the impact of age and study length.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.