Evidence map›Paper›PMID 24876448›Full record

Trial reportJournal of diabetes science and technology2014

Accuracy of a novel noninvasive transdermal continuous glucose monitor in critically ill patients.

Nicole M Saur, Michael R England, Wayne Menzie, Ann Marie Melanson, My-Quyen Trieu, Jason Berlin, James Hurley, Keith Krystyniak, Gail L Kongable, Stanley A Nasraway

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of diabetes science and technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicole M SaurDepartments of Surgery/Anesthesiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
Michael R EnglandDepartments of Surgery/Anesthesiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
Wayne MenzieEcho Therapeutics, Inc, Philadelphia, PA, USA.
Ann Marie MelansonDepartments of Surgery/Anesthesiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
My-Quyen TrieuEcho Therapeutics, Inc, Philadelphia, PA, USA.
Jason BerlinEcho Therapeutics, Inc, Philadelphia, PA, USA.
James HurleyEcho Therapeutics, Inc, Philadelphia, PA, USA.
Keith KrystyniakEcho Therapeutics, Inc, Philadelphia, PA, USA.
Gail L KongableThe Epsilon Group, Charlottesville, VA, USA.
Stanley A NasrawayDepartments of Surgery/Anesthesiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA Snasraway@tuftsmedicalcenter.org.
Tufts Medical Center · USThe Epsilon Group · USTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress hyperglycemia and hypoglycemia are associated with increased morbidity and mortality in the critically ill. Intermittent, random blood glucose (BG) measurements can miss episodes of hyper- and hypoglycemia. The purpose of this study was to determine the accuracy of the Symphony® continuous glucose monitor (CGM) in critically ill cardiac surgery patients. Fifteen adult cardiac surgery patients were evaluated immediately postoperatively in the intensive care unit. Prelude® SkinPrep prepared the skin and a sensor was applied to 2 test sites on each subject to monitor interstitial fluid glucose. Reference BG was sampled at 30- to 60-minute intervals. The skin at the test sites was inspected for adverse effects. Accuracy of the retrospectively analyzed CGM data relative to reference BG values was determined using continuous glucose-error grid analysis (CG-EGA) and mean absolute relative difference (MARD). Using 570 Symphony CGM glucose readings paired with reference BG measurements, CG-EGA showed that 99.6% of the readings were within zones A and B. BG measurements ranged from 73 to 251 mg/dL. The MARD was 12.3%. No adverse device effects were reported. The Symphony CGM system is able to safely, continuously, and noninvasively monitor glucose in the transdermal interstitial fluid of cardiac surgery intensive care unit patients with accuracy similar to that reported with other CGM systems. Future versions of the system will need real-time data analysis, fast warm-up, and less frequent calibrations to be used in the clinical setting.

Indexed as

AdultAgedAged, 80 and overBiosensing TechniquesBlood GlucoseCritical IllnessFemaleHumansHyperglycemiaHypoglycemiaMaleMiddle AgedMonitoring, PhysiologicReproducibility of ResultsBlood Glucosebiosensorcontinuous glucosediabetesintensive caretight glycemictransdermal

Identifiers

PMID24876448
PMCPMC4455366
OpenAlexW2118566091

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.