Trial reportCardiovascular diabetology2014
Multiple risk factor intervention reduces carotid atherosclerosis in patients with type 2 diabetes.
Trial report in Cardiovascular diabetology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00660790 (Multifactorial Treatment of Cardiovascular Risk in Patients With Diabetes Mellitus Type-2), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multifactorial Treatment of Cardiovascular Risk in Patients With Diabetes Mellitus Type-2: Identification of Treatment Non-Responders (The CARDIONOR Study)
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- HbA1c below 7% as the goal of glucose control fails to maximize the cardiovascular benefits: a meta-analysis.Cardiovascular diabetology · 2015Pooled it
- Association between markers of glycemia and carotid intima-media thickness: the MARK study.BMC cardiovascular disorders · 2016Trial
- The association of ideal cardiovascular health and its change with subclinical atherosclerosis according to glucose status: A prospective cohort study.Journal of diabetes · 2024Article
- Review
- Intensified Multifactorial Intervention in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2023Review
- Carotid Artery Disease in Subjects with Type 2 Diabetes: Risk Factors and Biomarkers.Journal of clinical medicine · 2021Article
- Association of Hepatic Steatosis Index and Fatty Liver Index with Carotid Atherosclerosis in Type 2 Diabetes.International journal of medical sciences · 2021Observational
- Application of an artificial neural network model for diagnosing type 2 diabetes mellitus and determining the relative importance of risk factors.Epidemiology and health · 2018Article
- Observational
- Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study.Cardiovascular diabetology · 2015Observational
- Assessment of Carotid Artery Stenosis and the Use of Statins.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015Article
- Decreased urine uric acid excretion is an independent risk factor for chronic kidney disease but not for carotid atherosclerosis in hospital-based patients with type 2 diabetes: a cross-sectional study.Cardiovascular diabetology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with rapid progression of carotid intima media thickness (CIMT) were shown to have a higher future risk for cardiovascular events.The aim of this study was to investigate the impact of multiple risk factor intervention on CIMT progression and to establish whether new cardiovascular surrogate measurements would allow prediction of CIMT changes. MATERIALS AND
methodsIn this prospective, open, 2-years study, we included 97 patients with type 2 diabetes and at least two insufficiently treated cardiovascular risk factors, i.e. HbA1c > 7.5% (58 mmol/mol); LDL-cholesterol >3.1 mmol/l or blood pressure >140/90 mmHg. Treatment was intensified according to current guidelines over 3 months with the aim to maintain intensification over 2 years.The primary outcome was the change in CIMT after 2 years. We also assessed markers of mechanical and biochemical endothelial function and endothelial progenitor cells before and after 3 months of treatment intensification. For testing differences between before and after multifactorial treatment measurements we used either the paired student's t-test or the Wilcoxon signed-rank test, depending on the distribution of the data. Additional, explorative statistical data analysis was done on CIMT progression building a linear multivariate regression model.
resultsBlood glucose, lipids and blood pressure significantly improved during the first 3 months of intensified treatment, which was sustained over the 2-year study duration. Mean CIMT significantly decreased from baseline to 2 year (0.883 ± 0.120 mm vs. 0.860 ± 0.130 mm; p = 0.021). None of the investigated surrogate measures, however, was able to predict changes in IMT early after treatment intensification.
conclusionsIntensification of risk factor intervention in type 2 diabetes results in CIMT regression over a period of 2 years. None of the biomarkers used including endothelial function parameters or endothelial progenitor cells turned out to be useful to predict CIMT changes.
trial registrationClinical Trial Registration - Unique identifier: NCT00660790.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.