ArticleFrontiers in human neuroscience2014
Comparative genomics of brain size evolution.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Comparative Principles for Next-Generation Neuroscience.Frontiers in behavioral neuroscience · 2019Article
- Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis.Molecular biology and evolution · 2018Article
- Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates.Genome biology and evolution · 2017Article
- Genetics of Cerebellar and Neocortical Expansion in Anthropoid Primates: A Comparative Approach.Brain, behavior and evolution · 2017Article
- MCPH1: a window into brain development and evolution.Frontiers in cellular neuroscience · 2015Review
- Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution.PloS one · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Which genetic changes took place during mammalian, primate and human evolution to build a larger brain? To answer this question, one has to correlate genetic changes with brain size changes across a phylogeny. Such a comparative genomics approach provides unique information to better understand brain evolution and brain development. However, its statistical power is limited for example due to the limited number of species, the presumably complex genetics of brain size evolution and the large search space of mammalian genomes. Hence, it is crucial to add functional information, for example by limiting the search space to genes and regulatory elements known to play a role in the relevant cell types during brain development. Similarly, it is crucial to experimentally follow up on hypotheses generated by such a comparative approach. Recent progress in understanding the molecular and cellular mechanisms of mammalian brain development, in genome sequencing and in genome editing, promises to make a close integration of evolutionary and experimental methods a fruitful approach to better understand the genetics of mammalian brain size evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.