Evidence map›Paper›PMID 24910262›Full record

ReviewTrends in neurosciences2014

Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins.

Amy E Ghiretti, Suzanne Paradis

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Imaging Structural and Functional Dynamics inCold Spring Harbor protocols · 2022
    Article
  4. Review
  5. Review
  6. Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  7. Review
  8. Article
  9. Article
  10. Two Components of Aversive Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amy E GhirettiDepartment of Biology, National Center for Behavioral Genomics, and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA.
Suzanne ParadisDepartment of Biology, National Center for Behavioral Genomics, and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA. Electronic address: paradis@brandeis.edu.

Funding

NEUROSCIENCE: FROM CHANNELS TO BEHAVIORT32MH019929 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 1994 to 2023
$8.5M
Semaphorin-Dependent GABAergic Synapse Formation: A Novel Approach to Increasing Inhibition in the Intact BrainR01NS065856 · NINDS · BRANDEIS UNIVERSITY · PI PARADIS, SUZANNE · 2010 to 2024
$5.4M
The Role of the Activity-Regulated GTPase Rem2 in Dendrite DevelopmentF31DA032181 · NIDA · BRANDEIS UNIVERSITY · PI GHIRETTI, AMY ELIZABETH · 2012 to 2013
$54k
NIDA NIH HHS F31 DA032181NIDA NIH HHS F31DA032181NIMH NIH HHS T32 MH019929NINDS NIH HHS R01 NS065856NINDS NIH HHS R01NS065856
6 · The paper itself

Abstract

The nervous system has the amazing capacity to transform sensory experience from the environment into changes in neuronal activity that, in turn, cause long-lasting alterations in neuronal morphology. Recent findings indicate that, surprisingly, sensory experience concurrently activates molecular signaling pathways that both promote and inhibit dendritic complexity. Historically, a number of positive regulators of activity-dependent dendritic complexity have been described, whereas the list of identified negative regulators of this process is much shorter. In recent years, there has been an emerging appreciation of the importance of the Rad/Rem/Rem2/Gem/Kir (RGK) GTPases as mediators of activity-dependent structural plasticity. In the following review, we discuss the traditional view of RGK proteins, as well as our evolving understanding of the role of these proteins in instructing structural plasticity.

Indexed as

AnimalsDendritesHumansMonomeric GTP-Binding ProteinsNeuronal PlasticityNeuronsSignal TransductionMonomeric GTP-Binding ProteinsactivitydendriteplasticityRGK

Identifiers

PMID24910262
PMCPMC4113564

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.