SynthesisWorld journal of gastroenterology2014
Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis.
Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis.PloS one · 2023Pooled it
- AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia.Gastroenterology · 2020Guideline
- Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy.Journal of clinical laboratory analysis · 2026Article
- Design and Characterization of Novel Gastroretentive Drug Delivery System of Antibiotics and Piperine for the Eradication ofMolecular pharmaceutics · 2025Article
- Effect of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Efficacy and potential mechanisms of jatrorrhizine on MNNG-induced chronic atrophic gastritis in rats based on serological metabolomics and molecular docking.Scientific reports · 2025Article
- Review
- Predictors of the Development of Gastric Cancer in Post-Cancers · 2025Article
- Article
- Long-term endoscopic gastric mucosal changes up to 20 years after Helicobacter pylori eradication therapy.Scientific reports · 2024Article
- A case of nodular gastritis progression to autoimmune gastritis after 10 years of Helicobacter pylori eradication.Clinical journal of gastroenterology · 2024Article
- Association between country of birth and gastric intestinal metaplasia: a retrospective cohort study.Lancet regional health. Americas · 2023Article
- Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.Molecules (Basel, Switzerland) · 2023Article
- Characteristics and background mucosa status of early gastric cancer after Helicobacter pylori eradication: A narrative review.Medicine · 2022Review
- Gastric mucosal precancerous lesions inWorld journal of gastroenterology · 2022Article
- Clinical outcomes of metachronous recurrence of gastric epithelial neoplasia based on Helicobacter pylori infection status and microsatellite stability.The Korean journal of internal medicine · 2022Article
- Lamb's tripe extract and vitamin BWorld journal of clinical cases · 2021Article
- Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost-effectiveness analysis.Helicobacter · 2021Article
- Risk of Progression of Gastric Intestinal Metaplasia Is Significantly Greater When Detected in Both Antrum and Body.Digestive diseases and sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo systematically review pathological changes of gastric mucosa in gastric atrophy (GA) and intestinal metaplasia (IM) after Helicobacter pylori (H. pylori) eradication.
methodsA systematic search was made of PubMed, Web of Science, EMBASE, ClinicalTrials.gov, OVID and the Cochran Library databases for articles published before March 2013 pertaining to H. pylori and gastric premalignant lesions. Relevant outcomes from articles included in the meta-analysis were combined using Review Manager 5.2 software. A Begg's test was applied to test for publication bias using STATA 11 software. χ(2) and I(2) analyses were used to assess heterogeneity. Analysis of data with no heterogeneity (P > 0.1, I (2) < 25%) was carried out with a fixed effects model, otherwise the causes of heterogeneity were first analyzed and then a random effects model was applied.
resultsThe results of the meta-analysis showed that the pooled weighted mean difference (WMD) with 95%CI was 0.23 (0.18-0.29) between eradication and non-eradication of H. pylori infection in antral IM with a significant overall effect (Z = 8.19; P <0.00001) and no significant heterogeneity (χ(2) = 27.54, I(2) = 16%). The pooled WMD with 95%CI was -0.01 (-0.04-0.02) for IM in the corpus with no overall effect (Z = 0.66) or heterogeneity (χ(2) = 14.87, I(2) =0%) (fixed effects model). In antral GA, the pooled WMD with 95% CI was 0.25 (0.15-0.35) with a significant overall effect (Z = 4.78; P < 0.00001) and significant heterogeneity (χ(2) = 86.12, I(2) = 71%; P < 0.00001). The pooled WMD with 95% CI for GA of the corpus was 0.14 (0.04-0.24) with a significant overall effect (Z = 2.67; P = 0.008) and significant heterogeneity (χ(2) = 44.79, I(2) = 62%; P = 0.0003) (random effects model).
conclusionH. pylori eradication strongly correlates with improvement in IM in the antrum and GA in the corpus and antrum of the stomach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.