ArticleFrontiers in physiology2014
Effect of contraction intensity on sympathetic nerve activity to active human skeletal muscle.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of a new resistance training method on the metaboreflex in cardiac rehabilitation patients: a randomized controlled trial.European journal of applied physiology · 2024Trial
- Sex differences in the relationship between pain and autonomic outflow during a cold pressor test.Biology of sex differences · 2025Article
- Effects of Performing Applied Muscle Tension during Recovery after Phlebotomy in Young, First-Time Donors: A Pilot Study.International journal of environmental research and public health · 2021Article
- The Role of Central Command in the Increase in Muscle Sympathetic Nerve Activity to Contracting Muscle During High Intensity Isometric Exercise.Frontiers in neuroscience · 2021Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage.Antioxidants (Basel, Switzerland) · 2020Article
- A Comparison of Muscle Sympathetic Nerve Activity to Non-contracting Muscle During Isometric Exercise in the Upper and Lower Limbs.Frontiers in neuroscience · 2019Article
- Muscle sympathetic outflow during exercise: a tale of two limbs.The Journal of physiology · 2018Article
- Sympathetic Discharges in intercostal and abdominal nerves.Physiological reports · 2018Article
- The metaboreflex does not contribute to the increase in muscle sympathetic nerve activity to contracting muscle during static exercise in humans.The Journal of physiology · 2018Article
- Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.Frontiers in neuroscience · 2018Review
- Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command.American journal of physiology. Heart and circulatory physiology · 2018Article
- Rate of rise in diastolic blood pressure influences vascular sympathetic response to mental stress.The Journal of physiology · 2016Article
- Contributions of Central Command and Muscle Feedback to Sympathetic Nerve Activity in Contracting Human Skeletal Muscle.Frontiers in physiology · 2016Article
- Interactive effect of acute sympathetic activation and exercise intensity on the dynamic response characteristics of vascular conductance in the human calf muscle.European journal of applied physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of contraction intensity on muscle sympathetic nerve activity (MSNA) to active human limbs has not been established. To address this, MSNA was recorded from the left peroneal nerve during and after dorsiflexion contractions sustained for 2 min by the left leg at ~10, 25, and 40% MVC. To explore the involvement of the muscle metaboreflex, limb ischemia was imposed midway during three additional contractions and maintained during recovery. Compared with total MSNA at rest (11.5 ± 4.1 mv(.)min(-1)), MSNA in the active leg increased significantly at the low (21.9 ± 13.6 mv(.)min(-1)), medium (30.5 ± 20.8 mv(.)min(-1)), and high (50.0 ± 24.5 mv(.)min(-1)) intensities. This intensity-dependent effect was more strongly associated with increases in MSNA burst amplitude than burst frequency. Total MSNA then returned to resting levels within the first minute of recovery. Limb ischemia had no significant influence on the intensity-dependent rise in MSNA or its decline during recovery in the active leg. These findings reveal intensity-dependent increases in total MSNA and burst amplitude to contracting human skeletal muscle that do not appear to involve the muscle metaboreflex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.