Insulin × glycemic control

SynthesisPloS one2014

Conventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis.

Ying Wu et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2014

Not counted

Probably raised glycemic control

+23%+10% to +35%

Bigger than 2 in 10 for glycemic control

As reported

OR 1.23, 95% CI 1.10–1.35

Not counted

Probably lowered glycemic control

−19%−33% to −5%

Bigger than 2 in 10 for glycemic control

As reported

OR 0.81, 95% CI 0.67–0.95

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower adverse events & safety

−15%−23% to −8%

Bigger than 4 in 10 for adverse events & safety

As reported

OR 0.85, 95% CI 0.77–0.92

Correlation · may be no link

No clear link with adverse events & safety

−16%−39% to +6%

Bigger than 5 in 10 for adverse events & safety

As reported

OR 0.84, 95% CI 0.61–1.06

Correlation · may be no link

No clear link with adverse events & safety

+10%−7% to +26%

Bigger than 3 in 10 for adverse events & safety

As reported

OR 1.10, 95% CI 0.93–1.26

+5 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

15% reduction in risk of lung cancer (OR 0.85, 95% CI 0.77 to 0.92), but this finding was not supported by sub-analysis of smoking-adjusted studies (OR 0.84, 95% CI 0.61 to 1.06).

lung cancer risk, respectively (OR 1.10, 95% CI 0.93 to 1.26), (OR 0.86, 95% CI 0.70 to 1.02).

cancer risk was related to insulin (OR 1.23, 95% CI 1.10 to 1.35).

did not change for metformin (OR 0.81, 95% CI 0.67 to 0.95),

for other glucose-lowering drugs was 0.87 (95% CI 0.81 to 0.94).

for other glucose-lowering drugs was 1.22 (95% CI 1.17 to 1.27).

risk in patients with diabetes (OR 1.10, 95% CI 0.93 to 1.26; P = 0.000

still increased lung cancer risk (OR 1.30, 95% CI 1.09 to 1.51).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
OR 0.850.77–0.92
Adverse events & safety
OR 0.840.61–1.06
Adverse events & safety
OR 1.100.93–1.26
Adverse events & safety
OR 0.860.70–1.02
Glycemic control
OR 1.231.10–1.35
Glycemic control
OR 0.810.67–0.95
Glycemic control
−0.87−0.94 to −0.81
Glycemic control
−1.22−1.27 to −1.17
Adverse events & safety
OR 1.100.93–1.26
Glycemic control
OR 1.301.09–1.51
MetforminSulfonylureas & glinidesInsulinOther glucose-loweringGlycemic controlAdverse events & safetyPharmacokinetics & dosing
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