Evidence map›Paper›PMID 24925122›Full record

Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2014

Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes.

C L Falconer, A R Cooper, J P Walhin, D Thompson, A S Page, T J Peters, A A Montgomery, D J Sharp, C M Dayan, R C Andrews

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Impact of Physical Activity in Patients With Type 2 Diabetes.American journal of lifestyle medicine · 2025
    Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Examining the Links Between Physical Activity, Sitting Time, and Renal Function in T2DM Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C L FalconerCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, UK; National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol, UK. Electronic address: Catherine.falconer@bristol.ac.uk.
A R CooperCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, UK; National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol, UK.
J P WalhinDepartment for Health, University of Bath, Bath, UK.
D ThompsonDepartment for Health, University of Bath, Bath, UK.
A S PageCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, UK.
T J PetersSchool of Clinical Sciences, University of Bristol, Bristol, UK.
A A MontgomeryNottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.
D J SharpSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
C M DayanInstitute of Clinical Diabetes and Metabolism, Cardiff University School of Medicine, Cardiff, UK.
R C AndrewsSchool of Clinical Sciences, University of Bristol, Bristol, UK.

Funding

Department of Health PB-PG-0610-22352
6 · The paper itself

Abstract

BACKGROUND AND

aimsWe investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. METHODS AND

resultsWe studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.

conclusionsHigher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.

Indexed as

Motor ActivitySedentary BehaviorAdiponectinAgedBiomarkersBody Mass IndexC-Reactive ProteinCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansInflammationIntercellular Adhesion Molecule-1Interleukin-6MaleAdiponectinBiomarkersC-Reactive ProteinICAM1 protein, humanIntercellular Adhesion Molecule-1Interleukin-6Breaks in sedentary timeInflammationSedentary timeType 2 diabetes

Identifiers

PMID24925122
PMCPMC4154448

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.