ArticleAntioxidants & redox signaling2014
Redox regulation of ion channels.
Article in Antioxidants & redox signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 66 citations in OpenAlex.
- Extracellular Redox Balance as a Determinant of Immune Regulation and Tissue Inflammation.Antioxidants (Basel, Switzerland) · 2026Review
- Redox Homeostasis in Metabolic Syndrome and Type II Diabetes: Role of Skeletal Muscle and Impact of Gold-Standard Treatments.International journal of molecular sciences · 2025Review
- Modulation of Redox-Sensitive Cardiac Ion Channels.Antioxidants (Basel, Switzerland) · 2025Review
- Development and validation of predictive models for meige syndrome patients based on oxidative stress markers.Frontiers in immunology · 2025Article
- L-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats.Scientific reports · 2024Article
- IPAntioxidants (Basel, Switzerland) · 2024Article
- L-cysteine ethylester reverses the adverse effects of morphine on breathing and arterial blood-gas chemistry while minimally affecting antinociception in unanesthetized rats.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- Oxidative stress and ion channels in neurodegenerative diseases.Frontiers in physiology · 2024Review
- The epigenetic signatures of opioid addiction and physical dependence are prevented by D-cysteine ethyl ester and betaine.Frontiers in pharmacology · 2024Article
- RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.Neurobiology of disease · 2023Article
- RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus.bioRxiv : the preprint server for biology · 2023Article
- L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats.Frontiers in pharmacology · 2023Article
- Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats.Frontiers in pharmacology · 2023Article
- Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation.Biochemistry · 2022Review
- Redox signaling regulates skeletal muscle remodeling in response to exercise and prolonged inactivity.Redox biology · 2022Review
- Control of STIM and Orai function by post-translational modifications.Cell calcium · 2022Review
- Lysosomal CaNature communications · 2022Article
- L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats.Frontiers in pharmacology · 2022Article
- Insights Into the Role of Mitochondria in Vascular Calcification.Frontiers in cardiovascular medicine · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species and reactive nitrogen species (ROS/RNS) are often by-products of biochemical reactions, but are increasingly recognized as important second messengers involved in regulation of distinct cellular functions. Mild and reversible oxidation of certain amino acids within protein polypeptide chains is known to precisely control the function of transcription factors, protein kinases and phosphatases, receptors, pumps, ion channels, and so on. Conversely, under pathological conditions, high amounts of oxidants irreversibly oxidize DNA, lipids, and proteins and have deleterious effects on cells, ultimately causing cell death. ROS/RNS can thus be involved in the initiation and progression of many pathological conditions. Within this Forum, seven reviews and one original article summarize the current knowledge regarding redox regulation of various ion channels and ion conducting receptors. These include the recently identified mitochondrial Ca2+ uniporter and Orai Ca2+ channels, as well as selected members of the families of transient receptor potential, voltage-gated Ca2+, P2X, voltage-gated K+, and IP3R/RyR channels. In summary, all authors agree on the functional importance of redox-ion channel interplay. However, it is also clear that this is an emerging field of research where much has to be learned about intra- and extracellular sources, concentrations, and types of oxidants. Given their often short-lived nature and effective cellular buffering systems, the development of tools to measure local ROS production in living cells as well as detailed proteomic approaches to pinpoint protein targets and redox modifications are of importance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.