Evidence map›Paper›PMID 24934179›Full record

SynthesisMolecular psychiatry2015

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis.

A Masi, D S Quintana, N Glozier, A R Lloyd, I B Hickie, A J Guastella

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed, 24 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

248 citing papers in PubMed, 24 syntheses or guidelines pooled it, 444 citations in OpenAlex.

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  17. Theory of mind in Alzheimer's disease and amnestic mild cognitive impairment: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

A MasiAutism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.
D S QuintanaAutism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.ORCID 0000000328760004
N GlozierAutism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.
A R LloydInflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia.ORCID 0000000162778887
I B HickieAutism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.
A J GuastellaAutism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.
MIND Research Institute · USUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of non-diagnostic features in the pathophysiology of autism spectrum disorders (ASDs) is unclear. Increasing evidence suggests immune system alterations in ASD may be implicated in the severity of behavioral impairment and other developmental outcomes. The primary objective of this meta-analysis was to investigate if there is a characteristic abnormal cytokine profile in ASD compared with healthy controls (HCs). We identified relevant studies following a search of MEDLINE, EMBASE, PsycINFO, Web of Knowledge and Scopus. A meta-analysis was performed on studies comparing plasma and serum concentrations of cytokines in unmedicated participants with ASD and HCs. Results were reported according to PRISMA statement. Seventeen studies with a total sample size of 743 participants with ASD and 592 HC were included in the analysis. Nineteen cytokines were assessed. Concentrations of interleukin (IL)-1beta (P<0.001), IL-6 (P=0.03), IL-8 (P=0.04), interferon-gamma (P=0.02), eotaxin (P=0.01) and monocyte chemotactic protein-1 (P<0.05) were significantly higher in the participants with ASD compared with the HC group, while concentrations of transforming growth factor-β1 were significantly lower (P<0.001). There were no significant differences between ASD participants and controls for the other 12 cytokines analyzed. The findings of our meta-analysis identified significantly altered concentrations of cytokines in ASD compared to HCs, strengthening evidence of an abnormal cytokine profile in ASD where inflammatory signals dominate.

Indexed as

Autism Spectrum DisorderCytokinesDatabases, BibliographicHumansCytokines

Identifiers

PMID24934179
OpenAlexW2046989317

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.