ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Relationship of left ventricular global longitudinal strain with cardiac autonomic denervation as assessed byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Trial
- Adaptive servo-ventilation therapy improves cardiac sympathetic nerve activity, cardiac function, exercise capacity, and symptom in patients with chronic heart failure and Cheyne-Stokes respiration.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- Cardiac sympathetic nerve activity in the non-culprit lesion predicts poor prognosis in patients with STEMI.European journal of nuclear medicine and molecular imaging · 2026Article
- Cardiac sympathetic nerve activity following mitral transcatheter edge-to-edge repair verified byHeart and vessels · 2026Article
- Parkinson's disease subtypes and their relationship to dementia with Lewy bodies: a comparative neuroimaging analysis based on nigrostriatal degeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Multicenter development and validation of a probability-based model to diagnose Lewy body disease using ¹²³I-meta-iodobenzylguanidine.European journal of nuclear medicine and molecular imaging · 2026Article
- Exploratory Evaluation of the Predictive Value of Serum Neurofilament Light Chain for Autonomic Neuropathy in Hereditary Transthyretin Amyloidosis.Journal of clinical medicine · 2026Article
- Heterogeneity of dementia with lewy bodies: Insights from clinical presentations, neuropathology, and biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Effect of tofogliflozin on cardiac sympathetic nerve activity in type 2 diabetes mellitus patients with heart failure (TARGET-HF): rationale and design of the single-arm intervention trial.Cardiovascular diabetology. Endocrinology reports · 2025Article
- The Vagal Link: Autonomic Nervous System Dysfunction in Cardiac Amyloidosis.Journal of clinical medicine · 2025Review
- Enhanced visual illusions in Parkinson's disease with cardiovascular autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The neuronal imaging in cardiology: 123I-Biophysical reviews · 2025Review
- Illuminating the Hidden: Standardizing Cardiac MIBG Imaging for Sympathetic Dysfunction.Journal of nuclear medicine technology · 2025Review
- Article
- The Heart of the Matter: Cardiac Denervation Casts Doubt on the Brain-First Versus Body-First Hypothesis of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease.NPJ Parkinson's disease · 2024Article
- SympatheticAnnals of nuclear medicine · 2024Article
- Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship betweenEJNMMI research · 2024Article
- Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.Journal of Alzheimer's disease : JAD · 2024Article
- Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy.Clinical parkinsonism & related disorders · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe heart-to-mediastinum ratio (HMR) of (123)I-metaiodobenzylguanidine (MIBG) showed variations among institutions and needs to be standardized among various scinticamera-collimator combinations.
methodsA total of 225 phantom experiments were performed in 84 institutions to calculate cross-calibration coefficients of HMR. Based on phantom studies, a conversion coefficient for each camera-collimator system was created, including low-energy (LE, n = 125) and a medium-energy (ME, n = 100) collimators. An average conversion coefficient from the most common ME group was used to calculate the standard HMR. In clinical MIBG studies (n = 52) from three institutions, HMRs were standardized from both LE- and ME-type collimators and classified into risk groups of <1.60, 1.60-2.19, and ≥2.20.
resultsThe average conversion coefficients from the individual camera-collimator condition to the mathematically calculated reference HMR ranged from 0.55 to 0.75 for LE groups and from 0.83 to 0.95 for ME groups. The conversion coefficient of 0.88 was used to unify HMRs from all acquisition conditions. Using the standardized HMR, clinical studies (n = 52) showed good agreement between LE and ME types regarding three risk groups (κ = 0.83, P < .0001, complete agreement in 90%, 42% of the patients reclassified into the same risk group).
conclusionBy using the reference HMR and conversion coefficients for the system, HMRs with various conditions can be converted to the standard HMRs in a range of normal to low HMRs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.