ReviewSeminars in nuclear medicine2014
Clinical decision making with myocardial perfusion imaging in patients with known or suspected coronary artery disease.
Review in Seminars in nuclear medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Screening of Potential Cardiac Involvement in Competitive Athletes Recovering From COVID-19: An Expert Consensus Statement.JACC. Cardiovascular imaging · 2020Guideline
- Comparison of diagnostic accuracy of PET-derived myocardial blood flow parameters: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Pooled it
- Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020Guideline
- AI-based identification of patients who benefit from revascularization: a multicenter study.medRxiv : the preprint server for health sciences · 2025Article
- Characteristics and key differences between patient populations receiving imaging modalities for coronary artery disease diagnosis in the US.BMC cardiovascular disorders · 2023Article
- A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting.Advances in therapy · 2022Article
- Clinical experience with regadenoson SPECT myocardial perfusion imaging: insights into patient characteristics, safety, and impact of results on clinical management.The international journal of cardiovascular imaging · 2022Article
- Advanced technology in the risk stratification-based strategy: The way forward to keep going.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Visually estimated coronary artery calcium score improves SPECT-MPI risk stratification.International journal of cardiology. Heart & vasculature · 2021Article
- SPECT myocardial perfusion imaging-based ischemia-guided early coronary revascularization improves survival: More fuel to the fire.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Review
- Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management.Journal of personalized medicine · 2021Review
- Cases from a Busy Nuclear Cardiology Laboratory.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Stronger correlation with myocardial ischemia of high-sensitivity troponin T than other biomarkers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Long-Term Prognostic Value of Stress Perfusion Cardiovascular Magnetic Resonance Imaging.Current treatment options in cardiovascular medicine · 2019Review
- Myocardial perfusion in patients with suspected coronary artery disease: comparison between 320-MDCT and rubidium-82 PET.European radiology · 2018Article
- An Overview on Image Registration Techniques for Cardiac Diagnosis and Treatment.Cardiology research and practice · 2018Review
- PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Outcome of revascularisation in stable coronary artery disease without ischaemia: a Danish registry-based follow-up study.BMJ open · 2017Observational
- Impact of imaging protocol on left ventricular ejection fraction using gated-SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Myocardial perfusion imaging (MPI) to diagnose coronary artery disease (CAD) is best performed in patients with intermediate pretest likelihood of disease; unfortunately, pretest likelihood is often overestimated, resulting in the inappropriate use of perfusion imaging. A good functional capacity often predicts low risk, and MPI for diagnosing CAD should be reserved for individuals with poor exercise capacity, abnormal resting electrocardiography, or an intermediate or high probability of CAD. With respect to anatomy-based testing, coronary CT angiography has a good negative predictive value, but stenosis severity correlates poorly with ischemia. Therefore decision making with respect to revascularization may be limited when a purely noninvasive anatomical test is used. Regarding perfusion imaging, the diagnostic accuracies of SPECT, PET, and cardiac magnetic resonance are similar, though fewer studies are available with cardiac magnetic resonance. PET coronary flow reserve may offer a negative predictive value sufficiently high to exclude severe CAD such that patients with mild to moderate reversible perfusion defects can forego invasive angiography. In addition, combined anatomical and perfusion-based imaging may eventually offer a definitive evaluation for diagnosing CAD, even in higher risk patients. Any remarkable findings on single-photon emission computed tomography and PET MPI studies are valuable for prognostication. Furthermore, assessment of myocardial blood flow with PET is particularly powerful for prognostication as it reflects the end result of many processes that lead to atherosclerosis. Decision making with respect to revascularization is limited for cardiac MRI and PET MPI. In contrast, retrospective radionuclide studies have identified an ischemic threshold, but randomized trials are needed. In patients with at least moderately reduced left ventricular systolic function, viable myocardium as assessed by PET or MRI, appears to identify patients who benefit from revascularization, but well-executed randomized trials are lacking.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.