ArticleThe journal of nutrition, health & aging2014
Physical performance measures and polypharmacy among hospitalized older adults: results from the CRIME study.
Article in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association Between Polypharmacy and Physical Function in Older Adults: a Systematic Review.Journal of general internal medicine · 2019Pooled it
- What is polypharmacy? A systematic review of definitions.BMC geriatrics · 2017Pooled it
- Visual biofeedback training reduces quantitative drugs index scores associated with fall risk.BMC research notes · 2018Trial
- Multi-Institutional Drug Use Patterns in Hospitalized Older Patients: Retrospective Cross-Sectional Study.JMIR medical informatics · 2026Article
- Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy.European journal of ageing · 2024Article
- Prevalence and clinical implications of polypharmacy and potentially inappropriate medication in elderly patients with heart failure: results of six months' follow-up.Journal of geriatric cardiology : JGC · 2023Article
- Fat-Fit Patterns, Drug Consumption, and Polypharmacy in Older Adults: The EXERNET Multi-Center Study.Nutrients · 2021Article
- Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences.European geriatric medicine · 2021Review
- Epidemiology and associated factors of polypharmacy in older patients in primary care: a northern Italian cross-sectional study.BMC geriatrics · 2021Article
- Barriers to Access to Treatment for Hypertensive Patients in Primary Health Care of Less Developed Northwest China: A Predictive Nomogram.International journal of hypertension · 2021Article
- Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study.Scientific reports · 2020Article
- Physical Performance and Quality of Life in Older Adults: Is There Any Association between Them and Potential Drug Interactions in Polymedicated Octogenarians.International journal of environmental research and public health · 2019Article
- Polypharmacy Definitions for Multimorbid Older Adults Need Stronger Foundations to Guide Research, Clinical Practice and Public Health.Pharmacy (Basel, Switzerland) · 2019Review
- Medication use in older patients and age-blind approach: narrative literature review (insufficient evidence on the efficacy and safety of drugs in older age, frequent use of PIMs and polypharmacy, and underuse of highly beneficial nonpharmacological strategies).European journal of clinical pharmacology · 2019Review
- Factors associated with poor physical performance in older adults of 11 Peruvian high Andean communities.F1000Research · 2019Article
- A prediction model to identify hospitalised, older adults with reduced physical performance.BMC geriatrics · 2017Article
- Polypharmacy and Gait Performance in Community-dwelling Older Adults.Journal of the American Geriatrics Society · 2017Article
- Inappropriate Use of Proton Pump Inhibitors in Elderly Patients Discharged from Acute Care Hospitals.The journal of nutrition, health & aging · 2016Article
- Editorial: Frailty and Polypharmacy.The journal of nutrition, health & aging · 2016Article
- Routine deprescribing of chronic medications to combat polypharmacy.Therapeutic advances in drug safety · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association of polypharmacy and physical performance measures in a sample of elderly patients aged ≥65 years admitted to acute care hospitals. DESIGN, SETTING AND
participantsProspective study conducted among 1123 hospitalized older adults participating to the CRiteria to Assess Appropriate Medication Use among Elderly Complex Patients (CRIME) project. MEASUREMENTS: Physical performance was measured at hospital admission by the 4-meter walking speed (WS) and the grip strength (GS). Polypharmacy was defined as the use of ≥10 drugs during hospital stay.
resultsMean age of 1123 participants was 81.5±7.4 years and 576 (51.3%) were on polypharmacy. Prevalence of polypharmacy was higher in patients with low WS and GS. After adjusting for potential confounders, participants in the highest tertile of WS were less likely to be on polypharmacy as compared with those in the lowest tertile (OR 0.58; 95% CI 0.35 - 0.96). Similarly, participants in the highest tertile of GS had a significantly lower likelihood of polypharmacy as compared with those in the lowest tertile (OR 0.55; 95% CI 0.36 - 0.84). When examined as continuous variables, WS and GS were inversely associated with polypharmacy (WS: OR 0.77 per 1 SD increment; 95% CI 0.60 - 0.98; GS: OR 0.71 per 1 SD increment; 95% CI 0.56 - 0.90).
conclusionAmong hospitalized older adults WS and GS are inversely related to polypharmacy. These measures should be incorporated in standard assessment of in-hospital patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.